Publication Name	World Journal of Clinical Oncology
Manuscript ID	106629
Country	Croatia

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Inclusion criteria for liver transplantation in patients with colorectal liver metastases: How to make the best selection?
Manuscript Source	Invited Manuscript
All Author List	Maja Cigrovski Berkovic, Anna Mrzljak, Fabio Melandro and Quirino Lai
Funding Agency and Grant Number
Corresponding Author	Maja Cigrovski Berkovic, Associate Professor, MD, PhD, Department for Sport and Exercise Medicine, University of Zagreb Faculty of Kinesiology, Horvacanski zavoj 15, Zagreb 10000, Croatia. maja.cigrovskiberkovic@gmail.com
Key Words	Colorectal carcinoma; Liver metastases; Liver transplantation; Donor characteristics; Recipient characteristics; Outcomes
Core Tip	Colorectal cancer liver metastases (CRLM) strongly impact patients’ survival despite available chemotherapy, surgical removal of liver metastases, and locoregional treatment alone or in combination with systemic chemotherapy. In the last few decades, liver transplantation (LT) in a selected patient population has significantly improved survival, nearing 83% during a 5-year follow-up. The selection of patients with CRLM for LT represents a significant challenge, requiring a balance between oncological outcomes and organ scarcity. Stringent criteria for eligible patient selection are key to long-term patient survival and can be summarized into those related to tumor biology and oncological factors, patient and donor characteristics, and previous response to therapy. Until more generalizable data are available, we explore and compare the inclusion and exclusion criteria used in various studies registered on ClinicalTrials.gov, highlighting their similarities, differences, and implications.
Citation	Cigrovski Berkovic M, Mrzljak A, Melandro F, Lai Q. Inclusion criteria for liver transplantation in patients with colorectal liver metastases: How to make the best selection? World J Clin Oncol 2025; In press

Received	2025-03-03 02:59
Peer-Review Started	2025-03-03 02:59
To Make the First Decision
Return for Revision	2025-03-14 06:15
Revised	2025-04-03 12:00
Second Decision	2025-05-21 02:51
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-21 14:05
Articles in Press	2025-05-21 14:05
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ISSN	2218-4333 (online)
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