Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	106707
Country	Italy

Category	Oncology
Manuscript Type	Minireviews
Article Title	Immune checkpoint inhibitors in the first-line treatment of esophageal squamous cell carcinoma: Minireview for a big shift
Manuscript Source	Invited Manuscript
All Author List	Giulia Massaro, Alexandra Paulet, Daniele Lavacchi, Marco Brugia, Daniele Rossini, Elisa Giommoni, Martina Catalano, Serena Pillozzi, Lorenzo Antonuzzo and Giandomenico Roviello
Funding Agency and Grant Number
Corresponding Author	Giandomenico Roviello, Associate Professor, MD, PhD, Department of Health Sciences, University of Florence, Viale Pieraccini, Florence 50134, Tuscany, Italy. giandomenico.roviello@unifi.it
Key Words	Esophageal squamous cell carcinoma; Immunotherapy; Immune checkpoint inhibitors; Programmed death ligand 1; First-line treatment
Core Tip	This paper examines the evolving landscape of first-line treatments for esophageal squamous cell carcinoma, highlighting the transformative impact of immune checkpoint inhibitors. While immune checkpoint inhibitors combined with chemotherapy have improved survival, response rates remain inconsistent due to variability in programmed death ligand 1 testing and immune microenvironment changes. We critically analyze landmark phase 3 trials (KEYNOTE-590, CheckMate 648) and discuss the limitations of current biomarkers. Addressing the urgent need for more precise patient selection and novel therapeutic strategies, this review provides insights into emerging approaches that could enhance long-term survival in esophageal squamous cell carcinoma.
Citation	<p>Massaro G, Paulet A, Lavacchi D, Brugia M, Rossini D, Giommoni E, Catalano M, Pillozzi S, Antonuzzo L, Roviello G. Immune checkpoint inhibitors in the first-line treatment of esophageal squamous cell carcinoma: Minireview for a big shift. <i>World J Gastrointest Oncol</i> 2025; 17(6): 106707</p>

Received	2025-03-05 11:30
Peer-Review Started	2025-03-05 11:30
To Make the First Decision
Return for Revision	2025-03-21 07:28
Revised	2025-04-09 08:12
Second Decision	2025-04-23 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-23 06:25
Articles in Press	2025-04-23 06:25
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-04-29 03:53
Typeset the Manuscript	2025-06-02 13:43

ISSN	1948-5204 (online)
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