Publication Name	World Journal of Gastroenterology
Manuscript ID	106835
Country	Egypt

Category	Gastroenterology & Hepatology
Manuscript Type	Systematic Reviews
Article Title	Exploring the gut-exercise link: A systematic review of gastrointestinal disorders in physical activity
Manuscript Source	Invited Manuscript
All Author List	Mohammed Al-Beltagi, Nermin Kamal Saeed, Adel Salah Bediwy, Yasser El-Sawaf, Akram Elbatarny and Reem Elbeltagi
Funding Agency and Grant Number
Corresponding Author	Mohammed Al-Beltagi, Chief Physician, MD, PhD, Professor, Department of Pediatrics, Faculty of Medicine, Tanta University, No. 1 Hassan Radwan Street, Tanta 31511, Al Gharbia, Egypt. mbelrem@hotmail.com
Key Words	Exercise; Gastrointestinal health; Gut-brain axis; Irritable bowel syndrome; Inflammatory bowel disease; Exercise-induced gastrointestinal disorders; Gut microbiota
Core Tip	This systematic review explores the complex relationship between exercise and gastrointestinal (GI) health, highlighting the dual effects of physical activity. Moderate-intensity exercises like walking and yoga promote intestinal motility, reduce systemic inflammation, and enhance gut barrier integrity, benefiting conditions like gastroesophageal reflux disease, irritable bowel syndrome, inflammatory bowel disease, and constipation. Conversely, high-intensity or prolonged exercise can exacerbate GI symptoms, such as nausea and diarrhea, due to splanchnic hypoperfusion and increased intestinal permeability. Individual responses vary based on fitness level, dietary habits, and underlying GI conditions, emphasizing the need for personalized exercise and dietary strategies. This systematic review underscores moderate exercise as a safe, effective intervention for optimizing GI health.
Citation	<p>Al-Beltagi M, Saeed NK, Bediwy AS, El-Sawaf Y, Elbatarny A, Elbeltagi R. Exploring the gut-exercise link: A systematic review of gastrointestinal disorders in physical activity. <i>World J Gastroenterol</i> 2025; 31(22): 106835</p>

Received	2025-03-09 09:13
Peer-Review Started	2025-03-09 09:13
To Make the First Decision
Return for Revision	2025-04-21 19:40
Revised	2025-04-27 00:08
Second Decision	2025-05-27 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-27 06:58
Articles in Press	2025-05-27 06:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-06-08 05:37

ISSN	1007-9327 (print) and 2219-2840 (online)
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