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Publication Name World Journal of Hepatology
Manuscript ID 106849
Country India
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Gut microbiota in non-alcoholic fatty liver disease: Pathophysiology, diagnosis, and therapeutics
Manuscript Source Invited Manuscript
All Author List Himani Pandey, Prabudh Goel, Varunvenkat M Srinivasan, Daryl W T Tang, Sunny H Wong and Devi Lal
Funding Agency and Grant Number
Corresponding Author Devi Lal, Assistant Professor, Department of Zoology, Ramjas College, University of Delhi, University Road, Near Department of Anthropology, University Enclave, Delhi 110007, Delhi, India. devilal@ramjas.du.ac.in
Key Words Non-alcoholic fatty liver disease; Gut microbiota; Gut-liver axis; Short-chain fatty acids; Bile acids; Mediterranean diet; Ketogenic diet; Probiotics; Prebiotics; Fecal microbiota transplantation
Core Tip Non-alcoholic fatty liver disease (NAFLD) is among the most prevalent chronic liver conditions that has been recognized as an emerging global health problem. Evidence suggests that the gut microbiota plays a critical role in the pathophysiology of NAFLD by influencing liver inflammation through its metabolites. Identifying gut microbial and metabolic signatures opens new avenues for early diagnosis and therapeutic interventions. Microbiota-targeted therapies, including diet, probiotics, prebiotics, synbiotics, and fecal microbiota transplantation, hold promise for alleviating NAFLD and improving patient outcomes.
Citation Pandey H, Goel P, Srinivasan VM, Tang DWT, Wong SH, Lal D. Gut microbiota in non-alcoholic fatty liver disease: Pathophysiology, diagnosis, and therapeutics. World J Hepatol 2025; In press
Received
2025-03-09 07:17
Peer-Review Started
2025-03-09 07:17
To Make the First Decision
Return for Revision
2025-03-19 12:26
Revised
2025-03-25 14:58
Second Decision
2025-05-19 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-05-21 14:23
Articles in Press
2025-05-21 14:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
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