Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	106898
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Retrospective Cohort Study
Article Title	Effects of low-density lipoprotein cholesterol on lymph node metastasis after radical esophagectomy
Manuscript Source	Unsolicited Manuscript
All Author List	Xin-Jian Xu, Shi-Wei Liu, Jia-Qi Li, Ming He, Hui Wang and Qing-Ju Meng
Funding Agency and Grant Number
Corresponding Author	Qing-Ju Meng, MD, Department of Oncology, the First Affiliated Hospital of Xingtai Medical College, No. 376 Shunde Road, Xingtai 054001, Hebei Province, China. hyd-xxj@163.com
Key Words	Esophageal cancer; Lymph node metastasis; Low-density lipoprotein cholesterol; B lymphocytes
Core Tip	This study investigated the relationship between pretreatment serum levels of low-density lipoprotein cholesterol (LDL-c) and lymph node (LN) metastasis in patients with esophageal cancer (EC) undergoing radical esophagectomy. Analysis of data from 294 patients revealed that elevated LDL-c levels significantly promoted LN metastasis, in contrast to the protective role of high-density lipoprotein. Further exploration using public databases and immunohistochemical techniques identified LRP5/6, particularly LRP6, as highly expressed in EC tissues, with LRP6 overexpression correlating with increased B-lymphocyte infiltration and adverse prognosis. Notably, patients with regional LN metastasis (N+ group) exhibited significantly higher expression of LRP6 and infiltrated B lymphocytes than those without regional LN metastasis (N0 group). Although CXCL13 expression remained comparable between the groups, CXCR5 expression was notably higher in the N0 group. These findings suggest that high serum LDL-c levels facilitate LN metastasis in EC, potentially through mechanisms involving LRP6 expression and B lymphocyte infiltration, thereby offering novel insights into the prognostic role of lipid profiles in EC progression.
Citation	Xu XJ, Liu SW, Li JQ, He M, Wang H, Meng QJ. Effects of low-density lipoprotein cholesterol on lymph node metastasis after radical esophagectomy. World J Gastrointest Surg 2025; In press

Received	2025-05-14 09:02
Peer-Review Started	2025-05-14 09:03
To Make the First Decision
Return for Revision	2025-05-30 02:03
Revised	2025-06-05 06:32
Second Decision	2025-07-11 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-11 06:09
Articles in Press	2025-07-11 06:09
Publication Fee Transferred	2025-06-11 05:54
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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