Publication Name	World Journal of Psychiatry
Manuscript ID	106906
Country	China

Category	Psychiatry
Manuscript Type	Retrospective Study
Article Title	Depressive state on cardiac remodeling and left ventricular function in chronic heart failure: A retrospective study
Manuscript Source	Unsolicited Manuscript
All Author List	Bo Gao, Yun-Fan Gao, Meng-Ting Chu and Ke-Fang Yuan
Funding Agency and Grant Number
Corresponding Author	Ke-Fang Yuan, Department of Cardiovascular Surgery, Hebei Petro China Central Hospital, No. 51 Xinkai Road, Langfang 065000, Hebei Province, China. yuankf198301@163.com
Key Words	Chronic heart failure; Depression; Cardiac remodeling; Left ventricular function; Inflammatory response
Core Tip	This study highlights a significant link between depression and cardiac remodeling in chronic heart failure (CHF) patients. Depression was associated with lower left ventricular ejection fraction, larger end-diastolic diameter, increased myocardial fibrosis, and elevated inflammatory and neuroendocrine markers. These findings suggest that depressive states exacerbate structural and functional cardiac abnormalities through inflammatory activation, neuroendocrine dysregulation, and enhanced oxidative stress. The results underscore the importance of psychological assessment and targeted management of depression in CHF patients. Addressing depression may mitigate its detrimental cardiovascular effects, offering a potential avenue to improve clinical outcomes and quality of life for patients with heart failure.
Citation	Gao B, Gao YF, Chu MT, Yuan KF. Depressive state on cardiac remodeling and left ventricular function in chronic heart failure: A retrospective study. World J Psychiatry 2025; In press

Received	2025-04-15 09:33
Peer-Review Started	2025-04-15 09:33
To Make the First Decision
Return for Revision	2025-05-13 10:36
Revised	2025-06-02 15:58
Second Decision	2025-07-09 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-09 07:33
Articles in Press	2025-07-09 07:33
Publication Fee Transferred	2025-07-03 04:06
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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