Publication Name	World Journal of Hepatology
Manuscript ID	106991
Country	Viet Nam

Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Role of mac-2 binding protein glycosylation isomer in predicting fibrosis in patients with metabolic dysfunction-associated steatotic liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Thuy Thi Thu Pham, Dat Tan Ho, Chanh Pham, Hoan Phan, Bieu Phu, Toan Nguyen, Dang Nguyen, Hai Thanh Phan and Khue Minh Nguyen
Funding Agency and Grant Number
Corresponding Author	Khue Minh Nguyen, Senior Scientist, Department of Genetics, Ho Chi Minh University of Science, 227 Nguyen Van Cu, District 5, Ho Chi Minh 700000, Viet Nam. minhkhuenguyen8888@gmail.com
Key Words	Diabetes; Magnetic resonance elastography; Mac-2 binding protein glycosylation isomer; Cirrhosis; Liver fibrosis; Metabolic dysfunction-associated steatotic liver disease
Core Tip	This study investigated the role of mac-2 binding protein glycosylation isomer (M2BPGi) as a novel biomarker for staging liver fibrosis in patients with metabolic dysfunction-associated steatotic liver disease in Viet Nam. It established the optimal cut-off values for M2BPGi across fibrosis stages (F0-F4), revealing a moderate correlation with FibroScan and magnetic resonance elastography findings. Ultimately, M2BPGi, Fibrosis-4 Index score, and hemoglobin A1c were identified as independent risk factors for greater fibrosis and cirrhosis (F4), emphasizing M2BPGi's potential in early detection and risk stratification.
Citation	Pham TTT, Ho DT, Pham C, Phan H, Phu B, Nguyen T, Nguyen D, Phan HT, Nguyen KM. Role of mac-2 binding protein glycosylation isomer in predicting fibrosis in patients with metabolic dysfunction-associated steatotic liver disease. World J Hepatol 2025; In press

Received	2025-03-13 07:40
Peer-Review Started	2025-03-13 07:40
To Make the First Decision
Return for Revision	2025-04-01 15:05
Revised	2025-04-30 10:17
Second Decision	2025-06-12 02:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-13 07:09
Articles in Press	2025-06-13 07:09
Publication Fee Transferred	2025-05-08 04:59
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-07-16 01:16

ISSN	1948-5182 (online)
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