| Category |
Oncology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Evaluating log odds of positive lymph nodes as a prognostic tool in differentiated gastric cancer: A retrospective study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ming-Cong Deng, Ken Chen, Qi-Mei Bao, Yi-Xing Huang, Chun-Kai Zhang, Yu-Ke Zhong, Han-Yi He, Dan Zu, Chen Liang, Hai-Dong Liu, Yang-Chan Hu, Guo-Xia Liu, Yan-Hua He, Wei-Xing Wu, Jing-Nan Zhou, Yao-Shu Teng, Ji Jing, Yin Shi, Clive Yik-Sham Chung, Chen-Huan Yu, Yi-An Du, Zu Ye and Xiang-Dong Cheng |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82473195 and No. 32370797 |
| Natural Science Foundation of Zhejiang Province |
No. LTGY23H160018 |
| Zhejiang Medical and Health Science and Technology Program |
No. 2024KY789 and No. 2023KY615 |
| National Research Center for Translational Medicine at Shanghai Program |
No. NRCTM(SH)-2025-07 |
| Beijing Science and Technology Innovation Medical Development Foundation |
No. KC2023-JX-0270-07 |
| Key Laboratory of Prevention, Diagnosis and Therapy of Upper Gastrointestinal Cancer of Zhejiang Province |
No. 2022E10021 |
|
| Corresponding Author |
Xiang-Dong Cheng, MD, Professor, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine, Chinese Academy of Sciences, No. 1 East Banshan Road, Hangzhou 310022, Zhejiang Province, China. yezuqscx@gmail.com |
| Key Words |
Gastric cancer; Log odds of positive lymph nodes; Tumor differentiation; Tumor marker; Overall survival |
| Core Tip |
This study highlights the log odds of positive lymph nodes (LODDS) as a reliable independent prognostic tool for moderately and poorly differentiated gastric cancer, providing more precise risk stratification than traditional systems such as pathologic N stage. Patients with higher LODDS values, which are associated with more aggressive tumor behavior, may benefit from more frequent follow-ups and intensified treatments. The incorporation of the LODDS into a clinical nomogram is expected to improve individualized survival prediction and the development of therapeutic strategies. |
| Citation |
Deng MC, Chen K, Bao QM, Huang YX, Zhang CK, Zhong YK, He HY, Zu D, Liang C, Liu HD, Hu YC, Liu GX, He YH, Wu WX, Zhou JN, Teng YS, Jing J, Shi Y, Chung CYS, Yu CH, Du YA, Ye Z, Dong CX. Evaluating log odds of positive lymph nodes as a prognostic tool in differentiated gastric cancer: A retrospective study. World J Gastroenterol 2025; In press |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
