Publication Name	World Journal of Psychiatry
Manuscript ID	107147
Country	China

Category	Psychiatry
Manuscript Type	Retrospective Cohort Study
Article Title	Depression and anxiety in patients with endometriosis-associated chronic pain: Neuroimmune mechanisms mediated by inflammatory factors
Manuscript Source	Unsolicited Manuscript
All Author List	Fan-Chun Yang, Yang Zhou, Shi-Yun Zhang and Rui Ma
Funding Agency and Grant Number
Corresponding Author	Rui Ma, MD, Department of Obstetrics and Gynecology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, No. 301 Yanchang Middle Road, Jing’an District, Shanghai 200072, China. ruima127@163.com
Key Words	Endometriosis; Chronic pain; Depression; Anxiety; Inflammation; Neuroimmune; Cytokines; Brain-derived neurotrophic factor
Core Tip	Endometriosis-associated chronic pain is frequently accompanied by depression and anxiety, but the underlying mechanisms remain unclear. This study highlights the role of inflammatory biomarkers, including interleukin-6, interleukin-1β, tumor necrosis factor-alpha, C-reactive protein, and brain-derived neurotrophic factor, in mediating these psychological comorbidities. Higher inflammatory marker levels correlate with increased pain severity and psychological distress. These findings suggest a neuroimmune link between endometriosis and mental health conditions, providing potential therapeutic targets. Addressing inflammation may improve both physical and psychological symptoms, emphasizing the need for an integrated treatment approach in managing endometriosis patients.
Citation	Yang FC, Zhou Y, Zhang SY, Ma R. Depression and anxiety in patients with endometriosis-associated chronic pain: Neuroimmune mechanisms mediated by inflammatory factors. World J Psychiatry 2025; In press

Received	2025-05-23 11:54
Peer-Review Started	2025-05-23 11:54
To Make the First Decision
Return for Revision	2025-06-17 03:19
Revised	2025-06-24 17:25
Second Decision	2025-08-19 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-19 07:35
Articles in Press	2025-08-19 07:35
Publication Fee Transferred	2025-07-04 08:15
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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