Publication Name	World Journal of Transplantation
Manuscript ID	107149
Country	United States

Category	Transplantation
Manuscript Type	Retrospective Cohort Study
Article Title	Increase in failed swallows from pre- to post-lung transplant esophageal function testing is associated with acute rejection
Manuscript Source	Invited Manuscript
All Author List	Wai-Kit Lo, Pranay Nadella, Natan Feldman, Nirmal Sharma, Hilary J Goldberg and Walter W Chan
Funding Agency and Grant Number
Corresponding Author	Walter W Chan, AGAF, Associate Professor, FACG, MD, Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women’s Hospital, 75 Francis Street, Boston, MA 02115, United States. wwchan@bwh.harvard.edu
Key Words	Esophageal dysmotility; High-resolution manometry; Ineffective esophageal motility; Failed swallows; Lung transplantation; Acute rejection
Core Tip	Gastroesophageal reflux has been associated with poor outcomes after lung transplantation, though the pathophysiology remains unclear. Lung transplantation itself may modulate this risk through impacts on pulmonary function and intrathoracic pressures, which alters esophageal motility to affect bolus clearance and reflux severity. Our study demonstrated that increased failed swallows from pre- to post-transplant testing was associated with increased risk of acute rejection after lung transplant, and was inversely correlated with baseline percent-predicted total lung capacity. The physiologic impact of lung transplantation may therefore affect esophageal function and contribute to rejection outcomes, suggesting a need for routine manometric testing in this high-risk patient population.
Citation	Lo WK, Nadella P, Feldman N, Sharma N, Goldberg HJ, Chan WW. Increase in failed swallows from pre- to post-lung transplant esophageal function testing is associated with acute rejection. World J Transplant 2025; In press

Received	2025-03-17 08:08
Peer-Review Started	2025-03-17 08:08
To Make the First Decision
Return for Revision	2025-04-01 05:40
Revised	2025-04-14 07:47
Second Decision	2025-05-19 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-21 14:27
Articles in Press	2025-05-21 14:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3230 (online)
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