Publication Name	World Journal of Methodology
Manuscript ID	107169
Country	United Kingdom

Category	Gastroenterology & Hepatology
Manuscript Type	Systematic Reviews
Article Title	Exploring effectiveness of Metronidazole, Bismuth, and Rifaximin in treating small intestinal bacterial overgrowth and irritable bowel syndrome: A systematic review
Manuscript Source	Invited Manuscript
All Author List	Qaim Shah and Jonathan Soldera
Funding Agency and Grant Number
Corresponding Author	Jonathan Soldera, PhD, Learna Ltd. in Association with University of South Wales, Treforest, Cardiff CF37 1DL, United Kingdom. jonathansoldera@gmail.com
Key Words	Small intestinal bacterial overgrowth; Irritable bowel syndrome; Rifaximin; Metronidazole; Bismuth
Core Tip	This study compares the efficacy and safety of Metronidazole, Bismuth, and Rifaximin in managing small intestinal bacterial overgrowth (SIBO) and irritable bowel syndrome (IBS). Rifaximin showed the greatest clinical benefit, particularly in diarrhea-predominant IBS patients, with minimal side effects. Metronidazole was effective for SIBO but associated with higher gastrointestinal side effects. Bismuth demonstrated some effectiveness, particularly in combination therapies, but was less pronounced than the other two antibiotics. Further research is needed to optimize treatment strategies and assess long-term outcomes.
Citation	Shah Q, Soldera J. Exploring effectiveness of Metronidazole, Bismuth, and Rifaximin in treating small intestinal bacterial overgrowth and irritable bowel syndrome: A systematic review. World J Methodol 2025; In press

Received	2025-03-17 08:38
Peer-Review Started	2025-03-25 09:11
To Make the First Decision
Return for Revision	2025-04-14 03:54
Revised	2025-04-21 20:06
Second Decision	2025-07-08 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-08 09:17
Articles in Press	2025-07-08 09:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2222-0682 (online)
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