Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	107211
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Stemness signatures reflect prognostic disturbances in gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Wen-Feng Pu, Xiao Yang, Xiao-Qing Wang, Xiao-Guang Guo and Mi-Yuan Yang
Funding Agency and Grant Number
Corresponding Author	Wen-Feng Pu, Department of Gastroenterology, Beijing Anzhen Nanchong Hospital of Capital Medical University and Nanchong Central Hospital, No. 97 Renmin South Road, Shunqing District, Nanchong 637000, Sichuan Province, China. 1047951869@qq.com
Key Words	Gastric cancer; Gastric cancer stemness sensitive; Cancer stem cells; Gastric cancer stem cells; Niemann-Pick protein C2
Core Tip	The results of this study indicate that the proposed gastric cancer (GC) stemness sensitivity model offers prognostic value that exceeds that of conventional clinicopathological staging, therefore providing more precise guidance for clinical decision-making and post-treatment management. The strong positive association between Niemann-Pick type C2 (NPC2) expression and GC progression highlights NPC2 as a promising prognostic biomarker. However, the functional role of NPC2 in GC remains insufficiently characterized. In this study, cellular experiments demonstrated that elevated expression of NPC2 enhances tumor cell stemness, invasiveness, migratory capacity, and resistance to radiotherapy and standard chemotherapeutic agents.
Citation	Pu WF, Yang X, Wang XQ, Guo XG, Yang MY. Stemness signatures reflect prognostic disturbances in gastric cancer. World J Gastrointest Oncol 2025; In press

Received	2025-03-19 13:02
Peer-Review Started	2025-03-19 13:02
To Make the First Decision
Return for Revision	2025-04-09 01:50
Revised	2025-04-20 08:08
Second Decision	2025-05-22 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-22 06:48
Articles in Press	2025-05-22 06:48
Publication Fee Transferred	2025-04-22 08:53
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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