Publication Name	World Journal of Experimental Medicine
Manuscript ID	107220
Country	Italy

Category	Infectious Diseases
Manuscript Type	Observational Study
Article Title	Evaluation of short and long-term laboratory and instrumental findings in COVID-19 patients hospitalized in Tuscany
Manuscript Source	Invited Manuscript
All Author List	Caterina Silvestri, Cristina Stasi, Francesco Profili, Simone Bartolacci, Emiliano Sessa, Danilo Tacconi, Liliana Villari, Laura Carrozzi, Francesco Dotta, Elena Bargagli, Sandra Donnini, Luca Masotti, Laura Rasero, Federico Lavorini, Francesco Pistelli, Davide Chimera, Alessandra Sorano, Miriana D'alessandro, Martina Pacifici, Caterina Milli and Fabio Voller
Funding Agency and Grant Number	Funding Agency Grant Number Tuscany Region No. D55H20000210002
Corresponding Author	Cristina Stasi, Associate Professor, MD, PhD, Epidemiology Unit, Regional Health Agency of Tuscany, Via Pietro Dazzi 1, Florence 50141, Italy. cristina.stasi@ars.toscana.it
Key Words	Long COVID-19; SARS-CoV-2; Transaminases; Fibrin degradation fragment; Gamma-glutamyl transferase; Spirometry
Core Tip	Long coronavirus disease 2019 (COVID-19) is a chronic condition that occurs after the initial severe acute respiratory syndrome coronavirus 2 infection. This longitudinal observational cohort study evaluates the short-term and long-term laboratory and instrumental findings in COVID-19 patients, and was conducted in hospitals in Tuscany between March 1, 2020, and March 1, 2021. The results indicated that alterations in liver enzymes, hematocrit or hemoglobin, lymphocytes and neutrophils were associated with a risk of requiring oxygen therapy or experiencing spirometry abnormalities during follow-up. These imbalanced conditions may contribute to pulmonary dysfunction and warrant further investigation to define potential pulmonary abnormalities.
Citation	Silvestri C, Stasi C, Profili F, Bartolacci S, Sessa E, Tacconi D, Villari L, Carrozzi L, Dotta F, Bargagli E, Donnini S, Masotti L, Rasero L, Lavorini F, Pistelli F, Chimera D, Sorano A, D'alessandro M, Pacifici M, Milli C, Voller F. Evaluation of short and long-term laboratory and instrumental findings in COVID-19 patients hospitalized in Tuscany. World J Exp Med 2025; In press

Received	2025-03-25 07:12
Peer-Review Started	2025-03-28 09:21
To Make the First Decision
Return for Revision	2025-04-08 05:52
Revised	2025-04-17 22:30
Second Decision	2025-06-03 02:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-03 11:13
Articles in Press	2025-06-03 11:13
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ISSN	2220-315x (online)
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