Publication Name	World Journal of Diabetes
Manuscript ID	107335
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Meta-Analysis
Article Title	Sodium-glucose co-transporter 2 inhibitors improve insulin resistance and β-cell function in type 2 diabetes: A meta-analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Shang-Yu Chai, Ru-Ya Zhang, Zhi-Yuan Ning, Yi-Man Zheng, Rajpathak Swapnil and Li-Nong Ji
Funding Agency and Grant Number
Corresponding Author	Li-Nong Ji, MD, Professor, Department of Endocrinology, People’s Hospital of Peking University, Xicheng District, Beijing 100044, China. jiln@bjmu.edu.cn
Key Words	β-cell function; Homeostasis model assessment; Insulin resistance; Meta-analysis; Sodium-glucose co-transporter 2 inhibitors
Core Tip	This meta-analysis, based on 24 randomized controlled trials, showed that sodium-glucose cotransporter 2 (SGLT2) inhibitors significantly improve insulin resistance and β-cell function in patients with type 2 diabetes (T2D), as evidenced by reductions in homeostasis model assessment of insulin resistance and increases in β-cell function. These findings highlight the potential of SGLT2 inhibitors to alleviate insulin resistance and improve β-cell function beyond glucose lowering. These results provide novel insights into the therapeutic role of SGLT2 inhibitors in managing T2D and underscore their ability to modify disease progression by targeting key pathophysiological mechanisms.
Citation	Chai SY, Zhang RY, Ning ZY, Zheng YM, Swapnil R, Ji LN. Sodium-glucose co-transporter 2 inhibitors improve insulin resistance and β-cell function in type 2 diabetes: A meta-analysis. World J Diabetes 2025; In press

Received	2025-03-21 17:07
Peer-Review Started	2025-03-25 00:08
To Make the First Decision
Return for Revision	2025-03-27 09:40
Revised	2025-04-10 01:30
Second Decision	2025-06-03 10:29
Accepted by Journal Editor-in-Chief	2025-06-06 10:37
Accepted by Executive Editor-in-Chief	2025-06-10 08:05
Articles in Press	2025-06-10 08:05
Publication Fee Transferred	2025-04-15 06:26
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Typeset the Manuscript

ISSN	1948-9358 (online)
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