Publication Name	World Journal of Hepatology
Manuscript ID	107378
Country	Georgia

Category	Gastroenterology & Hepatology
Manuscript Type	Opinion Review
Article Title	Liver regeneration after partial hepatectomy: Triggers and mechanisms
Manuscript Source	Invited Manuscript
All Author List	Bakari Korchilava, Tamar Khachidze, Nino Megrelishvili, Lika Svanadze, Manana Kakabadze, Keti Tsomaia, Memed Jintcharadze and Dimitri Kordzaia
Funding Agency and Grant Number
Corresponding Author	Dimitri Kordzaia, MD, PhD, Professor, Alexandre Natishvili Institute of Morphology, Ivane Javakhishvili Tbilisi State University, Beliashvili Str. 78, Tbilisi 0159, Georgia. dimitri.kordzaia@tsu.ge
Key Words	Partial hepatectomy; Liver regeneration; Portal pressure; Portal flow; Cytokines and growth factors; Molecular pathways; Ductular reaction; Structural remodeling
Core Tip	This review synthesizes key triggers and molecular pathways of Liver regeneration after partial hepatectomy, emphasizing the central role of portal hemodynamics, cytokine signaling, and extracellular matrix remodeling. It highlights underexplored processes such as ductular reaction in granulation tissue, and the role of metabolic regulators like bile acids and glutamine. The paper outlines mechanisms of the termination of liver regenerative and proposes new perspectives for its therapeutic modulation in clinical settings.
Citation	Korchilava B, Khachidze T, Megrelishvili N, Svanadze L, Kakabadze M, Tsomaia K, Jintcharadze M, Kordzaia D. Liver regeneration after partial hepatectomy: Triggers and mechanisms. World J Hepatol 2025; In press

Received	2025-03-26 03:32
Peer-Review Started	2025-04-01 00:08
To Make the First Decision
Return for Revision	2025-04-11 09:57
Revised	2025-04-23 11:32
Second Decision	2025-06-10 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-10 11:22
Articles in Press	2025-06-10 11:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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