Publication Name	World Journal of Critical Care Medicine
Manuscript ID	107396
Country	United States

Category	Critical Care Medicine
Manuscript Type	Meta-Analysis
Article Title	Safety and early mobilization in intensive care unit patients: An updated systematic review and meta-analysis of randomized controlled trials
Manuscript Source	Invited Manuscript
All Author List	Syed A Khan, Abdul Moeed, Tahreem Mari, Zehra Yousuf, Arthur Hanson, Yue Dong, Patrick Cornelius, Humayun Anjum, Iqbal Ratnani and Salim Surani
Funding Agency and Grant Number
Corresponding Author	Salim Surani, MD, Professor, Department of Medicine and Pharmacology, Texas A&M University, 40 Bizzell Street, College Station, TX 77843, United States. srsurani@hotmail.com
Key Words	Early mobilization; Early mobility; Intensive care unit; Critical care unit; Mechanical ventilation; Functional outcomes; Randomized controlled trials; Rehabilitation
Core Tip	This updated systematic review and meta-analysis of 16 randomized controlled trials involving 2385 intensive care unit (ICU) patients demonstrates that initiating early mobilization (EM) (within 72 hours of ICU admission) significantly reduces ICU length of stay and mechanical ventilation duration while improving muscle strength and functional status. EM does not increase adverse events or mortality, supporting its safety and efficacy as a routine ICU intervention.
Citation	Khan SA, Moeed A, Mari T, Yousuf Z, Hanson A, Dong Y, Cornelius P, Anjum H, Ratnani I, Surani S. Safety and early mobilization in intensive care unit patients: An updated systematic review and meta-analysis of randomized controlled trials. World J Crit Care Med 2025; In press

Received	2025-03-24 07:39
Peer-Review Started	2025-03-24 07:39
To Make the First Decision
Return for Revision	2025-04-08 05:06
Revised	2025-04-17 02:49
Second Decision	2025-05-27 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-27 10:40
Articles in Press	2025-05-27 10:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3141(online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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