Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	107453
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Deoxycholic acid induces reactive oxygen species accumulation and promotes colorectal cancer cells apoptosis through CaMKII-Ca2+ pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Jia-Yan Chen, Jing-Yi Wen, Jia-Long Lin, Yan Li, Yi-Zhang Wu, Li-Qin Lou, Yong-Liang Lou, Zhi-Gui Zuo and Xiang Li
Funding Agency and Grant Number	Funding Agency Grant Number the Key Discipline of Zhejiang Province in Medical Technology (First Class, Category A) Wenzhou Science & Technological Project Y20240103
Corresponding Author	Xiang Li, Department of Health Inspection and Quarantine, School of Laboratory Medicine and Life Sciences, Institute of One Health, Wenzhou Medical University, Zhejiang Provincial Key Laboratory of Medical Genetics, Ministry of Education, No. 1 Qiuzhen Road, Wenzhou 325035, Zhejiang Province, China. yhx2008@163.com
Key Words	Deoxycholic acid; Reactive oxygen species; Mitochondrial calcium; Apoptosis; Colorectal cancer
Core Tip	This study reveals that deoxycholic acid (DCA) induces colorectal cancer (CRC) cell apoptosis via CaMKII-Ca2+ signaling. Using DLD-1/SW480 models, DCA elevated mitochondrial calcium and reactive oxygen species (ROS) levels, driving apoptosis. Calcium chelation reversed these effects, confirming calcium-ROS interplay as the core mechanism. The findings highlight disrupted calcium homeostasis and oxidative stress in DCA-associated carcinogenesis, providing new therapeutic targets for CRC intervention.
Citation	Chen JY, Wen JY, Lin JL, Li Y, Wu YZ, Lou LQ, Lou YL, Zuo ZG, Li X. Deoxycholic acid induces reactive oxygen species accumulation and promotes colorectal cancer cells apoptosis through CaMKII-Ca2+ pathway. World J Gastrointest Oncol 2025; In press

Received	2025-03-30 10:05
Peer-Review Started	2025-03-30 10:06
To Make the First Decision
Return for Revision	2025-04-22 12:22
Revised	2025-05-06 12:01
Second Decision	2025-06-09 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-09 08:30
Articles in Press	2025-06-09 08:30
Publication Fee Transferred	2025-05-21 02:12
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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