Publication Name	World Journal of Transplantation
Manuscript ID	107461
Country	Brazil

Category	Transplantation
Manuscript Type	Retrospective Study
Article Title	Serum factor V and arterial lactate levels predict graft survival in liver transplant recipients with aminotransferase above five thousand
Manuscript Source	Invited Manuscript
All Author List	Gabriel Lazzarotto-da-Silva, Bruno Marches Chaves, Flávia Heinz Feier, Pablo Duarte Rodrigues, Tomaz Jesus Maria Grezzana-Filho, Alexandre de Araujo, Mario Reis Alvares-da-Silva, Roberta Cabral Marchiori, Marcio Fernandes Chedid and Cleber Rosito Pinto Kruel
Funding Agency and Grant Number	Funding Agency Grant Number Financiamento e Incentivo à Pesquisa of Hospital de Clínicas de Porto Alegre No. 170271
Corresponding Author	Marcio Fernandes Chedid, MD, PhD, Professor, Liver Transplant and Hepatobiliary Surgery Unit, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, 2350, Porto Alegre 90035-007, Rio Grande do Sul, Brazil. mchedid@hcpa.edu.br
Key Words	Aminotransferase; Liver transplantation; Early allograft failure; Factor V; Lactate
Core Tip	Among 341 liver transplant recipients, 25 had an aminotransferase level > 5000 U/L. Early allograft failure (death or re-transplantation within 90 days) occurred in 11 patients. One-year and five-year graft survival rates were 51.7% and 42.6%, respectively. However, approximately 50% of these patients withstood initial graft injury and had a satisfactory long-term prognosis. Therefore, early identification of patients who will recover graft function or undergo graft loss is paramount. Serum factor V and arterial lactate levels can aid in deciding whether to relist patients to retransplantation early in the postoperative period.
Citation	Lazzarotto-da-Silva G, Chaves BM, Feier FH, Rodrigues PD, Grezzana-Filho TJM, de Araujo A, Alvares-da-Silva MR, Marchiori RC, Chedid MF, Kruel CRP. Serum factor V and arterial lactate levels predict graft survival in liver transplant recipients with aminotransferase above five thousand. World J Transplant 2025; In press

Received	2025-03-24 09:33
Peer-Review Started	2025-03-24 09:33
To Make the First Decision
Return for Revision	2025-04-01 05:55
Revised	2025-04-13 13:28
Second Decision	2025-05-21 02:51
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-21 14:43
Articles in Press	2025-05-21 14:43
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Typeset the Manuscript

ISSN	2220-3230 (online)
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