Publication Name	World Journal of Methodology
Manuscript ID	107468
Country	United States

Category	Medicine, General & Internal
Manuscript Type	Meta-Analysis
Article Title	Association of neutrophil-lymphocyte ratio with cardiovascular and all-cause mortality in patients receiving chronic hemodialysis: Systematic review and meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Roopeessh Vempati, Nanush Damarlapally, Srivatsa Surya Vasudevan, Viral Patel, Prathibha Banda, Denise Mourad, Harshavardhan Polamarasetty, Gaurav Mathur, Afrasayab Khan, Rupak Desai, Iqbal Ratnani and Salim Surani
Funding Agency and Grant Number
Corresponding Author	Salim Surani, MD, Professor, Department of Medicine & Pharmacology, Texas A&M University, 40 Bizzell Street, College Station, TX 77843, United States. srsurani@hotmail.com
Key Words	Neutrophil-lymphocyte ratio; Chronic hemodialysis; Cardiovascular mortality; All-cause mortality; Inflammation; Inflammatory markers; Dialysis outcomes; Hematological biomarkers; Dialysis-associated cardiovascular disease
Core Tip	This systematic review and meta-analysis evaluate the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) in patients undergoing chronic hemodialysis (HD). Elevated NLR was significantly associated with increased all-cause and cardiovascular mortality in this population. By pooling adjusted hazard ratios and assessing heterogeneity and diagnostic performance via the area under the curve, the study highlights NLR as a potentially valuable and accessible biomarker for risk stratification in HD patients. Findings support its clinical use, while emphasizing the need for standardized cutoffs and prospective validation.
Citation	<p>Vempati R, Damarlapally N, Vasudevan SS, Patel V, Banda P, Mourad D, Polamarasetty H, Mathur G, Khan A, Desai R, Ratnani I, Surani S. Association of neutrophil-lymphocyte ratio with cardiovascular and all-cause mortality in patients receiving chronic hemodialysis: Systematic review and meta-analysis. <i>World J Methodol</i> 2025; 15(4): 107468</p>

Received	2025-03-25 07:14
Peer-Review Started	2025-04-02 09:00
To Make the First Decision
Return for Revision	2025-04-18 01:29
Revised	2025-04-28 15:07
Second Decision	2025-06-18 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-18 08:03
Articles in Press	2025-06-18 08:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-07-07 10:25

ISSN	2222-0682 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com