Publication Name	World Journal of Gastroenterology
Manuscript ID	107478
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Deciphering lactate metabolism in colorectal cancer: Prognostic modeling, immune infiltration, and gene mutation insights
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Peng Wang, Jia-Xin Zhu, Chang Liu, Hao-Wen Zhang, Guan-Duo Sun, Jing-Ming Zhai, Hai-Jun Yang and De-Chun Liu
Funding Agency and Grant Number	Funding Agency Grant Number Henan Province Science and Technology Research Project 232102310043 Henan Provincial Science and Technology Research and Development Plan Joint Fund 222103810047 Key Scientific Research Project Plan of Colleges and Universities in Henan Province 22A320033
Corresponding Author	De-Chun Liu, PhD, Department of Gastrointestinal Surgery, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, No. 24 Jinghua Road, Jianxi District, Luoyang 471003, Henan Province, China. lydocliu666@163.com
Key Words	Colorectal cancer; Lactate metabolism; Prognostic model; Immune infiltration; Gene mutation analysis
Core Tip	This study presents a comprehensive analysis of lactate metabolism in colorectal cancer, identifying its pivotal role in shaping the tumor microenvironment and influencing immune infiltration. A predictive model utilizing a panel of seven lactate metabolism-related genes was developed, accurately predicting patient outcomes and drug sensitivity. Integration of transcriptomic and single-cell data highlights monocyte/macrophage metabolic activity, offering novel insights into personalized colorectal cancer therapy and the potential of targeting lactate metabolism to enhance treatment efficacy.
Citation	Wang XP, Zhu JX, Liu C, Zhang HW, Sun GD, Zhai JM, Yang HJ, Liu DC. Deciphering lactate metabolism in colorectal cancer: Prognostic modeling, immune infiltration, and gene mutation insights. World J Gastroenterol 2025; In press

Received	2025-03-27 03:20
Peer-Review Started	2025-03-27 03:20
To Make the First Decision
Return for Revision	2025-04-03 21:05
Revised	2025-05-03 03:13
Second Decision	2025-06-10 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-10 03:41
Articles in Press	2025-06-10 03:41
Publication Fee Transferred	2025-05-06 11:55
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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