Publication Name	World Journal of Hepatology
Manuscript ID	107520
Country	China

Category	Oncology
Manuscript Type	Minireviews
Article Title	Systemic treatment of liver cancer: Current status and future progress
Manuscript Source	Invited Manuscript
All Author List	Chun-Bo Li, Yu-Ting Ning, Nai-Ying Shen, Ben Wang, Han Xiao and Gang Luo
Funding Agency and Grant Number	Funding Agency Grant Number China-Shaanxi Nuclear Industry Group 61230303 Shaanxi Nuclear Industry 215 Hospital 215KYJJ-202214 Jiangxi Provincial Health Commission 202510800
Corresponding Author	Gang Luo, Department of General Surgery, Jiujiang First People's Hospital, No. 77 Balihu East Road, Balihu New District, Jiujiang 332000, Jiangxi Province, China. luogangxueshu@163.com
Key Words	Primary liver cancer; Systemic therapy; Molecularly targeted drugs; Immunosuppressive therapy; Combination therapy
Core Tip	Primary liver cancer is the malignant tumor with the fifth highest incidence in the world, and hepatocellular carcinoma is the most common among primary liver cancer. Due to the insidious disease onset and rapid progression, most liver cancer patients are diagnosed in the intermediate or advanced stages, and surgery is no longer a viable option. This article summarizes the current challenges faced by the systemic treatment of liver cancer and introduces the prospect of future treatment trends.
Citation	Li CB, Ning YT, Shen NY, Wang B, Xiao H, Luo G. Systemic treatment of liver cancer: Current status and future progress. World J Hepatol 2025; In press

Received	2025-03-26 03:30
Peer-Review Started	2025-04-03 09:09
To Make the First Decision
Return for Revision	2025-04-14 10:38
Revised	2025-04-26 14:31
Second Decision	2025-06-09 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-09 07:13
Articles in Press	2025-06-09 07:13
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-06-11 01:43
Typeset the Manuscript

ISSN	1948-5182 (online)
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