Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	107568
Country	China

Category	Medical Ethics
Manuscript Type	Case Report
Article Title	Descending duodenal adenocarcinoma treated with pembrolizumab resulting in complete clinical response: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Xiang-Lei Kong, Xi-Wei Lu, Si-Qi Dong, Jiao Liu, Lei Zheng, Lan-Lan Chen, Zi-Hui An, Li-Ming Gao and Jun-Li Cao
Funding Agency and Grant Number	Funding Agency Grant Number Medical Science Research Project of Hebei Province in 2023, Key Laboratory of Research on Molecular Mechanism of Gastrointestinal Tumors in Qinhuangdao 20231891
Corresponding Author	Jun-Li Cao, Department of Oncology, The First Hospital of Qinhuangdao, The Affiliated Qinhuangdao First Hospital of Hebei Medical University, No. 258 Wenhua Road, Qinhuangdao 066000, Hebei Province, China. kongxianglei@qhdsdyyy.com
Key Words	Duodenal malignancy; Microsatellite instability-high; High expression of programmed cell death-ligand 1; Pembrolizumab; Complete clinical response; Case report
Core Tip	Descending duodenal adenocarcinoma (DDA) is a rare malignancy of the digestive system. We treated a patient with DDA characterized by microsatellite instability-high (MSI-H) and high programmed cell death-ligand 1 expression, customizing the treatment regimen for individualized pembrolizumab therapy based on our clinical experience and disease assessment. The patient achieved long-term clinical remission with satisfactory results. This case underscores the advantages of individualized therapy and confirms that patients with mismatch-repair deficiency/MSI-H can derive significant benefits from pembrolizumab.
Citation	Kong XL, Lu XW, Dong SQ, Liu J, Zheng L, Chen LL, An ZH, Gao LM, Cao JL. Descending duodenal adenocarcinoma treated with pembrolizumab resulting in complete clinical response: A case report and review of literature. World J Gastrointest Oncol 2025; In press

Received	2025-03-27 02:28
Peer-Review Started	2025-03-27 02:28
To Make the First Decision
Return for Revision	2025-04-03 08:52
Revised	2025-04-16 15:21
Second Decision	2025-05-21 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-21 08:08
Articles in Press	2025-05-21 08:08
Publication Fee Transferred	2025-04-17 09:35
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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