Publication Name	World Journal of Nephrology
Manuscript ID	107582
Country	Italy

Category	Urology & Nephrology
Manuscript Type	Review
Article Title	Kidney involvement and anemia in COVID-19 infection
Manuscript Source	Invited Manuscript
All Author List	Guido Gembillo, Luigi Peritore, Giuseppe Spadaro, Felicia Cuzzola, Michela Calderone, Rossella Messina, Simona Di Piazza, Flavia Sudano, Maria Elsa Gambuzza, Maria Princiotto, Luca Soraci and Domenico Santoro
Funding Agency and Grant Number
Corresponding Author	Guido Gembillo, Unit of Nephrology and Dialysis, AOU "G. Martino", University of Messina, Via Consolare Valeria n 1, Messina 98125, Sicilia, Italy. ggembillo@gmail.com
Key Words	COVID 19; Hemodialysis; Renal transplant; Erythropoietin; Peritoneal dialysis; Iron deficiency; Renal anemia; Systemic inflammation; Renal replacement therapy
Core Tip	The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus, the causative agent of coronavirus disease-2019 (COVID-19) infection, has had a major impact worldwide. People with chronic kidney disease (CKD) and COVID-19 have an increased risk of mortality and hospitalization, with anemia, which is common in CKD, exacerbating outcomes. Patients with CKD show resistance to erythropoietin (EPO)-stimulating agents and require higher doses even after infection. Anemia in CKD is exacerbated by factors such as decreased EPO production, red blood cell fragmentation, iron or folic acid deficiency, platelet dysfunction and excessive hepcidin synthesis. These factors contribute to poor iron regulation, which further complicates anemia in COVID-19 patients.
Citation	Gembillo G, Peritore L, Spadaro G, Cuzzola F, Calderone M, Messina R, Di Piazza S, Sudano F, Gambuzza ME, Princiotto M, Soraci L, Santoro D. Kidney involvement and anemia in COVID-19 infection. World J Nephrol 2025; In press

Received	2025-03-26 03:43
Peer-Review Started	2025-03-28 00:10
To Make the First Decision
Return for Revision	2025-04-24 01:13
Revised	2025-05-07 23:15
Second Decision	2025-07-24 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-24 10:18
Articles in Press	2025-07-24 10:18
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-07-28 09:59
Typeset the Manuscript

ISSN	2220-6124 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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