Publication Name	World Journal of Psychiatry
Manuscript ID	107604
Country	China

Category	Neurosciences
Manuscript Type	Review
Article Title	Unraveling the mysteries of schizophrenia: Insights into prefrontal cortex dysfunction and therapeutic implications
Manuscript Source	Invited Manuscript
All Author List	Bing-Fei Cheng, Ye Liang and Qian Wu
Funding Agency and Grant Number
Corresponding Author	Qian Wu, Department of Orthopedic Surgery, Soochow University, No. 899 Pinghai Road, Suzhou 215123, China. qianwujoint@163.com
Key Words	Schizophrenia; Prefrontal cortex dysfunction; Structural abnormalities; Functional dysconnectivity; Microcircuit dysregulation; Therapeutic implications
Core Tip	Schizophrenia is characterized by cognitive deficits, emotional dysregulation, and executive dysfunction. This review highlights the central role of prefrontal cortex (PFC) dysfunction in the manifestation of these symptoms. Structural abnormalities, functional dysconnectivity, and microcircuit dysregulation within the PFC contribute significantly to the disorder’s pathology. A comprehensive understanding of these neurobiological mechanisms is vital for the development of targeted therapeutic approaches. Both pharmacological and non-pharmacological treatments aimed at modulating PFC activity show considerable promise in alleviating the core symptoms of schizophrenia. Ongoing research into PFC dysfunction remains essential for devising effective therapies and improving outcomes for individuals affected by this complex disorder.
Citation	Cheng BF, Liang Y, Wu Q. Unraveling the mysteries of schizophrenia: Insights into prefrontal cortex dysfunction and therapeutic implications. World J Psychiatry 2025; In press

Received	2025-03-28 04:36
Peer-Review Started	2025-04-06 08:32
To Make the First Decision
Return for Revision	2025-04-30 07:31
Revised	2025-05-21 16:42
Second Decision	2025-08-08 01:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-18 07:30
Articles in Press	2025-08-18 07:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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