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Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 107651
Country China
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Relationship between uric acid and colon cancer risk: Dose-response analysis and mechanisms
Manuscript Source Unsolicited Manuscript
All Author List Teng-Fei Sun, Ke-Xin Fan, Yu-Xin Luo, Jia Song, Zhuo-Xiao Han and Xiao-Lan Zhang
Funding Agency and Grant Number
Corresponding Author Xiao-Lan Zhang, Professor, Department of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Gastroenterology, Hebei Institute of Gastroenterology, Hebei Clinical Research Center for Digestive Diseases, No. 80 Huanghe Road, Yuhua District, Shijiazhuang 050000, Hebei Province, China. xiaolanzh@hebmu.edu.cn
Key Words Uric acid; Colon cancer; Reactive oxygen species; Phosphoinositide 3-kinases; Mammalian target of rapamycin
Core Tip This study, encompassing 2020 colon cancer cases and 6060 controls, revealed an inverse association between uric acid levels and the risk of colon cancer. To delve deeper into the underlying mechanisms, we conducted in vitro experiments using colon cancer cells. Our findings demonstrated that uric acid potently inhibits cell proliferation and migration. Mechanistically, these effects were mediated by the induction of reactive oxygen species and the suppression of the phosphoinositide 3-kinases/protein kinase B/mammalian target of rapamycin signaling pathway.
Citation Sun TF, Fan KX, Luo YX, Song J, Han ZX, Zhang XL. Relationship between uric acid and colon cancer risk: Dose-response analysis and mechanisms. World J Gastrointest Oncol 2025; In press
Received
2025-03-28 02:43
Peer-Review Started
2025-03-28 02:43
To Make the First Decision
Return for Revision
2025-04-04 00:10
Revised
2025-05-03 08:25
Second Decision
2025-06-30 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-06-30 09:24
Articles in Press
2025-06-30 09:24
Publication Fee Transferred
2025-05-08 02:05
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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