Publication Name	World Journal of Diabetes
Manuscript ID	107663
Country	China

Category	Cell Biology
Manuscript Type	Minireviews
Article Title	Spatial transcriptomics meets diabetic kidney disease: Illuminating the path to precision medicine
Manuscript Source	Invited Manuscript
All Author List	Dan-Dan Liu, Han-Yue Hu, Fei-Fei Li, Qiu-Yue Hu, Ming-Wei Liu, You-Jin Hao and Bo Li
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Research Program of Chongqing Municipal Education Commission No. KJQN202100538 Talent Innovation Project in Life Sciences of Chongqing Normal University No. CSSK2023-04
Corresponding Author	Bo Li, Associate Professor, PhD, College of Life Sciences, Chongqing Normal University, No. 37 University City Middle Road, Shapingba District, Chongqing 401331, China. libcell@cqnu.edu.cn
Key Words	Diabetic kidney disease; Spatial transcriptomics; Single-cell RNA sequencing; Renal microenvironment; Precision medicine; Computational biology
Core Tip	This mini-review highlights the emerging role of spatial transcriptomics (ST) in diabetic kidney disease (DKD) research. ST enables high-resolution mapping of gene expression within intact tissues, offering novel insights into cellular interactions, lesion-specific transcriptional changes, and immune infiltration. The mini-review further discusses the integration of ST with computational tools such as machine learning and network analysis, and its potential in precision diagnostics and therapy. Despite challenges in spatial resolution and data complexity, ST is poised to transform DKD research by bridging molecular discovery with clinical application.
Citation	Liu DD, Hu HY, Li FF, Hu QY, Liu MW, Hao YJ, Li B. Spatial transcriptomics meets diabetic kidney disease: Illuminating the path to precision medicine. World J Diabetes 2025; In press

Received	2025-03-28 07:20
Peer-Review Started	2025-04-03 09:07
To Make the First Decision
Return for Revision	2025-05-09 13:27
Revised	2025-05-23 04:39
Second Decision	2025-08-06 10:57
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-15 10:17
Articles in Press	2025-08-15 10:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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