Publication Name	World Journal of Hepatology
Manuscript ID	107666
Country	China

Category	Immunology
Manuscript Type	Basic Study
Article Title	Tumor necrosis factor alpha-induced protein 3: A key biomarker for response to ursodeoxycholic acid in primary biliary cholangitis
Manuscript Source	Unsolicited Manuscript
All Author List	Bo Zang, Jia-Xiu Li, Qi-Xuan Liu, Yuan Yao, Hua Li, Yan Wang, Ji-Gang Wang, Yi-Fei Yang, Rui-Wen Liang, Xin-Ran Xin and Bin Liu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 81671600 and No. 81241094 Natural Science Foundation of Shandong Province, China No. ZR2016HM13 and No. ZR2023MH066 Qingdao Medical and Health Scientific Research Project, China No. 2024-WJKY160
Corresponding Author	Bin Liu, MD, PhD, Department of Rheumatology and Immunology, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao 266001, Shandong Province, China. binliu72314@163.com
Key Words	Primary biliary cholangitis; Bioinformatics analysis; Tumor necrosis factor alpha-induced protein 3; Biomarkers; Predictor; Therapeutic target
Core Tip	By bioinformatics analysis, we identified 13 differentially expressed genes linked to primary biliary cholangitis progression. Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) was selected for validation via immunohistochemistry and confirmed as a promising biomarker for ursodeoxycholic acid response. Clinical validation further proved its significant correlation with treatment outcomes. Additionally, fatigue was identified as an independent predictor of ursodeoxycholic acid efficacy, and the combination of TNFAIP3 expression and fatigue exhibited superior predictive performance. The expression of TNFAIP3 was also associated with key clinicopathological features, including age, albumin levels, total bilirubin, alkaline phosphatase, and splenomegaly, providing new insights into disease progression.
Citation	Zang B, Li JX, Liu QX, Yao Y, Li H, Wang Y, Wang JG, Yang YF, Liang RW, Xin XR, Liu B. Tumor necrosis factor alpha-induced protein 3: A key biomarker for response to ursodeoxycholic acid in primary biliary cholangitis. World J Hepatol 2025; In press

Received	2025-03-30 10:42
Peer-Review Started	2025-04-08 09:02
To Make the First Decision
Return for Revision	2025-04-30 07:37
Revised	2025-05-10 15:13
Second Decision	2025-06-25 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-25 07:26
Articles in Press	2025-06-25 07:26
Publication Fee Transferred	2025-05-12 05:08
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Typeset the Manuscript

ISSN	1948-5182 (online)
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