Publication Name	World Journal of Nephrology
Manuscript ID	107736
Country	Egypt

Category	Biochemistry & Molecular Biology
Manuscript Type	Basic Study
Article Title	Cardamom extract: An effective weapon in prevention of cardiorenal syndrome induced in rats by cisplatin and high-fat diet
Manuscript Source	Invited Manuscript
All Author List	Doha Mohamed, Ibrahim Hamed and Hoda B Mabrok
Funding Agency and Grant Number	Funding Agency Grant Number National Research Centre, Egypt 13050203
Corresponding Author	Doha Mohamed, Additional Professor, PhD, Professor, Department of Nutrition and Food Science, National Research Centre, 33 El Buhouth St, Ad Doqi, Dokki, Cairo Governorate 12622, Cairo 12622, Al Qāhirah, Egypt. dohaabdomohamed@gmail.com
Key Words	Cardiorenal syndrome; Cardamom extract; Hippo signaling pathway; Oxidative stress; Inflammatory markers; Phenolic compounds
Core Tip	In this study, cardiorenal syndrome (CRS) was experimentally induced in rats using a high-fat diet and cisplatin. The protective effects of crude ethanol extract (CEE) of cardamom were evaluated through comprehensive biochemical analyses. The potential mechanistic role of CEE phenolics was explored via molecular docking with the Hippo signaling pathway. The findings suggest that CEE, as a phenolic-rich dietary supplement, may protect against CRS by reducing inflammation and oxidative stress, and by targeting components of the Hippo pathway.
Citation	Mohamed D, Hamed I, Mabrok HB. Cardamom extract: An effective weapon in prevention of cardiorenal syndrome induced in rats by cisplatin and high-fat diet. World J Nephrol 2025; In press

Received	2025-03-28 07:09
Peer-Review Started	2025-04-01 00:10
To Make the First Decision
Return for Revision	2025-04-14 04:07
Revised	2025-04-20 21:55
Second Decision	2025-06-10 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-10 11:29
Articles in Press	2025-06-10 11:29
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Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
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