Publication Name	World Journal of Gastroenterology
Manuscript ID	107745
Country	Brazil

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Positioning and sequencing of advanced therapies in inflammatory bowel disease: A guide for clinical practice
Manuscript Source	Invited Manuscript
All Author List	Marcello Imbrizi, Matheus F C Azevedo, Julio P Baima, Natália S F Queiroz, Rogério S Parra, Sandro D C Ferreira, Ligia Y Sassaki and Julio Maria F Chebli
Funding Agency and Grant Number
Corresponding Author	Julio Maria F Chebli, Adjunct Associate Professor, MD, PhD, Senior Researcher, Division of Gastroenterology, Department of Medicine, University Hospital of the Federal University of Juiz de Fora, University of Juiz de Fora School of Medicine, Maria José Leal Street, 296, Juiz de Fora 36036-247, Minas Gerais, Brazil. julio.chebli@ufjf.br
Key Words	Inflammatory bowel disease; Crohn’s disease; Ulcerative colitis; Advanced therapy; Biologics; Sequencing; Treatment strategy; Janus kinase inhibitors; Biologic agents
Core Tip	One of the key challenges clinicians face in managing individuals with inflammatory bowel disease (IBD) is determining which advanced therapy to initiate and how to sequence treatments when needed. In the absence of readily available molecular markers, these decisions, although often complex, are guided by patient- and disease-specific factors, including disease severity, phenotype, complication risk, comorbidities, extraintestinal manifestations, the balance between drug efficacy and safety, convenience, and treatment access. In this review, we examine the various considerations influencing therapeutic decision-making in different IBD clinical contexts and offer practical tips to support more personalized approaches based on the individual’s clinical profile.
Citation	Imbrizi M, Azevedo MFC, Baima JP, Queiroz NSF, Parra RS, Ferreira SDC, Sassaki LY, Chebli JMF. Positioning and sequencing of advanced therapies in inflammatory bowel disease: A guide for clinical practice. World J Gastroenterol 2025; In press

Received	2025-03-30 11:27
Peer-Review Started	2025-03-30 11:27
To Make the First Decision
Return for Revision	2025-05-20 19:38
Revised	2025-06-03 01:59
Second Decision	2025-07-11 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-11 05:33
Articles in Press	2025-07-11 05:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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