Publication Name	World Journal of Stem Cells
Manuscript ID	107833
Country	Brazil

Category	Cell & Tissue Engineering
Manuscript Type	Review
Article Title	Mesenchymal stem cells-based therapy for peripheral nerve injuries: A promise or reality?
Manuscript Source	Invited Manuscript
All Author List	Lucas Vinícius de Oliveira Ferreira, Kelly Cristine Santos Roballo and Rogério Martins Amorim
Funding Agency and Grant Number	Funding Agency Grant Number São Paulo Research Foundation (FAPESP) 2024/19980-0
Corresponding Author	Lucas Vinícius de Oliveira Ferreira, Department of Veterinary Clinic, School of Veterinary Medicine and Animal Science, São Paulo State University, Prof. Dr. Walter Maurício Corrêa Street, s/n, Botucatu 18618-681, São Paulo, Brazil. lv.ferreira@unesp.br
Key Words	Cell-based therapies; Extracellular vesicles; Mesenchymal stem cells; Nerve guidance conduits; Nerve regeneration; Regenerative medicine
Core Tip	Mesenchymal stem cells (MSCs) offer a promising therapeutic approach for peripheral nerve injuries involving nerve gap by promoting axonal regeneration, modulating inflammation, secreting neurotrophic factors, and exhibiting transdifferentiation capacity. These properties position MSCs as a compelling alternative to conventional treatments. However, challenges still exist for the clinical use of MSCs, requiring further research to fully unlock their therapeutic potential and translate these advancements into effective nerve regeneration strategies.
Citation	Ferreira LVO, Roballo KCS, Amorim RM. Mesenchymal stem cells-based therapy for peripheral nerve injuries: A promise or reality? World J Stem Cells 2025; In press

Received	2025-03-31 09:41
Peer-Review Started	2025-03-31 09:41
To Make the First Decision
Return for Revision	2025-04-14 10:42
Revised	2025-04-23 22:48
Second Decision	2025-06-06 02:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-09 09:01
Articles in Press	2025-06-09 09:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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