Publication Name	World Journal of Hepatology
Manuscript ID	107963
Country	Pakistan

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Hope on the horizon: Emerging therapies for hepatitis D
Manuscript Source	Invited Manuscript
All Author List	Zaigham Abbas and Minaam Abbas
Funding Agency and Grant Number
Corresponding Author	Zaigham Abbas, AGAF, FACG, FACP, FRCP, Head, Professor, Department of Hepatogastroenterology, Dr. Ziauddin University Hospital Clifton, Clifton, Karachi 75600, Sindh, Pakistan. drzabbas@gmail.com
Key Words	Hepatitis D; Hepatitis B; Treatment; Pegylated interferon; Bulevirtide; Nucleic acid polymers; Lonafarnib; Tobevibart; Elebsiran
Core Tip	New therapeutic options for hepatitis D are emerging, offering hope for improved treatment outcomes. Pegylated interferon-alpha is currently the primary treatment for hepatitis D, but it has limitations, including significant adverse effects and low response rates. Several novel therapies are being developed. Bulevirtide, HH003, and tobevibart are entry inhibitors. Other drugs include pegylated interferon-lambda, a type III interferon; lonafarnib, a prenylation inhibitor that prevents viral replication with synergistic effects when combined with pegylated interferon-alpha; REP 2139, a nucleic acid polymer that inhibits virus entry and replication; and small interfering RNAs, including elebsiran that interfere with translation of hepatitis B virus RNA.
Citation	Abbas Z, Abbas M. Hope on the horizon: Emerging therapies for hepatitis D. World J Hepatol 2025; In press

Received	2025-04-02 07:35
Peer-Review Started	2025-04-02 07:35
To Make the First Decision
Return for Revision	2025-04-20 19:02
Revised	2025-04-22 19:46
Second Decision	2025-06-05 02:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-07 05:08
Articles in Press	2025-06-07 05:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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