Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	107974
Country	India

Category	Infectious Diseases
Manuscript Type	Minireviews
Article Title	Neonatal and pediatric sepsis: Microbiological insights, diagnostic innovations, and antimicrobial challenges
Manuscript Source	Invited Manuscript
All Author List	Basavraj S Nagoba, Shree V Dhotre, Mahesh N Sonar, Sachin S Mumbre, Ajay M Gavkare and Pradnya S Dhotre
Funding Agency and Grant Number
Corresponding Author	Basavraj S Nagoba, PhD, Professor, Department of Microbiology, Maharashtra Institute of Medical Sciences and Research (Medical College), Vishwanathpuram, Ambajogai Road, Latur 413531, Maharashtra, India. dr_bsnagoba@yahoo.com
Key Words	Sepsis biomarkers; Neonatal intensive care unit; Antimicrobial stewardship; Microbiome; AI in diagnostics; Neonatal infections
Core Tip	Neonatal and pediatric sepsis is a major contributor to global child mortality, with significant challenges in timely and accurate diagnosis. Traditional blood culture methods have limitations, necessitating advancements in molecular diagnostics and biomarker-based approaches. Emerging technologies such as metagenomic sequencing and artificial intelligence -driven diagnostic tools offer promising solutions for rapid pathogen identification. Antimicrobial resistance continues to complicate treatment, making antimicrobial stewardship programs crucial in pediatric healthcare. This review highlights microbiological insights, diagnostic advancements, antimicrobial resistance mechanisms, combination therapy strategies, and approaches to improving early detection and outcomes in pediatric sepsis.
Citation	Nagoba BS, Dhotre SV, Sonar MN, Mumbre SS, Gavkare AM, Dhotre PS. Neonatal and pediatric sepsis: Microbiological insights, diagnostic innovations, and antimicrobial challenges. World J Clin Pediatr 2025; In press

Received	2025-04-03 03:16
Peer-Review Started	2025-04-03 03:16
To Make the First Decision
Return for Revision	2025-04-15 02:28
Revised	2025-04-21 09:28
Second Decision	2025-06-05 02:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-07 05:12
Articles in Press	2025-06-07 05:12
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-06-11 21:49
Typeset the Manuscript

ISSN	2219-2808 (online)
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Copyright	©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
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