Publication Name	World Journal of Clinical Oncology
Manuscript ID	108112
Country	Bosnia and Herzegovina

Category	Neurosciences
Manuscript Type	Minireviews
Article Title	Glucose and antidiabetic therapy in temozolomide resistance in glioblastoma
Manuscript Source	Invited Manuscript
All Author List	Emir Begagić, Amina Džidić-Krivić, Hakija Bečulić, Ragib Pugonja, Adnana Ljevaković, Binasa Bašić, Adem Nuhović, Elma Milanović, Semir Hadžić, Emir Bećirović, Lemana Buljubašić, Minela Bećirović and Mirza Pojskić
Funding Agency and Grant Number
Corresponding Author	Emir Begagić, Academic Editor, MD, Department of Neurosurgery, Cantonal Hospital Zenica, Crkvice 67, Zenica 72000, Bosnia and Herzegovina. begagicem@gmail.com
Key Words	Drug resistance; Glioblastoma multiforme; Neoplasms; Glucose metabolism; Antidiabetic drugs
Core Tip	Metformin shows promise as an adjunct therapy in glioblastoma by modulating glucose metabolism, enhancing temozolomide efficacy, and targeting glioma stem cells. Its ability to cross the blood-brain barrier and influence pathways such as AMPK and Wnt highlights its potential. However, its impact on survival remains unclear, requiring further clinical validation.
Citation	Begagić E, Džidić-Krivić A, Bečulić H, Pugonja R, Ljevaković A, Bašić B, Nuhović A, Milanović E, Hadžić S, Bećirović E, Buljubašić L, Bećirović M, Pojskić M. Glucose and antidiabetic therapy in temozolomide resistance in glioblastoma. World J Clin Oncol 2025; In press

Received	2025-04-08 15:20
Peer-Review Started	2025-04-08 15:20
To Make the First Decision
Return for Revision	2025-04-17 11:01
Revised	2025-04-25 22:42
Second Decision	2025-06-25 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-25 07:00
Articles in Press	2025-06-25 07:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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