Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	108150
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Integrating nutritional and inflammatory biomarkers in colorectal cancer management: Implications of microsatellite instability status
Manuscript Source	Invited Manuscript
All Author List	Ren-Xian Xie, Yi-Xuan Xing and Nian-Zhe Sun
Funding Agency and Grant Number
Corresponding Author	Nian-Zhe Sun, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Kaifu District, Changsha 410008, Hunan Province, China. sunnzh201921@sina.com
Key Words	Prognostic markers; Personalized medicine; Inflammatory indices; Nutritional biomarkers; Microsatellite instability; Colorectal cancer
Core Tip	Zuo et al demonstrate that colorectal cancer patients with microsatellite instability (MSI) exhibit distinct nutritional and inflammatory profiles, including lower serum albumin, body mass index, and lymphocyte counts, alongside elevated neutrophil-to-lymphocyte ratios. These differences underscore the potential of MSI status to guide tailored nutritional support and immunomodulatory therapies, addressing the unique pathophysiological needs of MSI-high patients. Future research should explore how these biomarkers influence treatment responses and long-term survival.
Citation	Xie RX, Xing YX, Sun NZ. Integrating nutritional and inflammatory biomarkers in colorectal cancer management: Implications of microsatellite instability status. World J Gastrointest Surg 2025; In press

Received	2025-04-07 04:30
Peer-Review Started	2025-04-07 04:30
To Make the First Decision
Return for Revision	2025-05-22 09:46
Revised	2025-05-24 02:16
Second Decision	2025-07-11 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-11 07:19
Articles in Press	2025-07-11 07:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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