Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	108239
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Compound spleen-tonifying composition alleviates dextran sulfate sodium-induced ulcerative colitis in rats
Manuscript Source	Unsolicited Manuscript
All Author List	Wen-Cui Zhao, Qing-Lan Zhao, Yan Zhang, Nan Zhao, Jia-Qi Tian, Yan-Yun Wu and Wei Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Jilin Province Science and Technology Development Plan Project 20210204012YY
Corresponding Author	Yan-Yun Wu, Quality Management Department, The 964th Hospital of the Joint Logistics Support Force, No. 4799 Xi'an Road, Lvyuan District, Changchun 130062, Jilin Province, China. wyy964yy@163.com
Key Words	Ulcerative colitis; Compound spleen-tonifying composition; Dextran sulfate sodium; Oxidative stress; Inflammation
Core Tip	This study reveals that the compound spleen-tonifying composition (CSTC), a traditional Chinese medicine formula, alleviates ulcerative colitis (UC) through dual modulation of oxidative stress, inflammation and tight junction protein expression. Crucially, bioactivity is polarity-dependent: Polar solvent extracts (ethyl acetate/n-butanol) show superior efficacy to non-polar extracts in restoring intestinal barrier integrity, reducing dextran sulfate sodium-induced damage, and normalizing inflammatory/oxidative markers. This is the first report establishing extraction methodology as a critical determinant of CSTC’s therapeutic effects, providing a novel strategy for optimizing herbal formulations against UC.
Citation	Zhao WC, Zhao QL, Zhang Y, Zhao N, Tian JQ, Wu YY, Zhang W. Compound spleen-tonifying composition alleviates dextran sulfate sodium-induced ulcerative colitis in rats. World J Gastrointest Surg 2025; In press

Received	2025-06-05 09:08
Peer-Review Started	2025-06-05 09:08
To Make the First Decision
Return for Revision	2025-07-08 05:39
Revised	2025-07-22 07:30
Second Decision	2025-08-18 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-18 06:34
Articles in Press	2025-08-18 06:34
Publication Fee Transferred	2025-07-28 07:40
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Typeset the Manuscript

ISSN	1948-9366 (online)
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