Publication Name	World Journal of Clinical Oncology
Manuscript ID	108279
Country	China

Category	Oncology
Manuscript Type	Editorial
Article Title	Rosmarinic acid as a chemosensitizer in colorectal cancer: Targeting nuclear factor-kappa B pathway to overcome chemoresistance
Manuscript Source	Invited Manuscript
All Author List	Yun-Yun Xu, Wen-Jing Chen, Yu-Jie Cai, Feng Lin and Zhi-Peng He
Funding Agency and Grant Number
Corresponding Author	Zhi-Peng He, MD, PhD, Visiting Professor, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Shushan District, Hefei 230000, Anhui Province, China. hezhipeng0901@163.com
Key Words	Rosmarinic acid; Colorectal cancer; Nuclear factor-kappa B signaling; Chemoresistance; Chemosensitizer; Natural products
Core Tip	This study demonstrates that rosmarinic acid (RA), a natural polyphenol, suppresses colorectal cancer progression by inhibiting nuclear factor-kappa B signaling and synergizes with chemotherapeutics (5-fluorouracil/oxaliplatin) to overcome drug resistance. RA’s dual role as a cytotoxic agent and chemosensitizer highlights its potential in precision oncology. While in vitro findings are promising, future research must address RA’s bioavailability, in vivo efficacy, and clinical safety to translate this natural compound into actionable colorectal cancer therapies.
Citation	Xu YY, Chen WJ, Cai YJ, Lin F, He ZP. Rosmarinic acid as a chemosensitizer in colorectal cancer: Targeting nuclear factor-kappa B pathway to overcome chemoresistance. World J Clin Oncol 2025; In press

Received	2025-04-10 07:15
Peer-Review Started	2025-04-10 07:15
To Make the First Decision
Return for Revision	2025-04-28 09:18
Revised	2025-05-08 08:51
Second Decision	2025-06-30 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-30 10:46
Articles in Press	2025-06-30 10:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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