Publication Name	World Journal of Stem Cells
Manuscript ID	108523
Country	China

Category	Cell & Tissue Engineering
Manuscript Type	Review
Article Title	Stem cell-based cartilage regeneration: Biological strategies, engineering innovations, and clinical translation
Manuscript Source	Unsolicited Manuscript
All Author List	Bo Cong, Feng-Hua Zhang and Hai-Guang Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Yantai Science and Technology Innovation Development Plan Project 2023YD048
Corresponding Author	Hai-Guang Zhang, Department of Orthopaedics, Yantaishan Hospital, Yantaishan Hospital Affiliated to Binzhou Medical University, Yantai Key Laboratory for Repair and Reconstruction of Bone & Joint, No. 10087 Science and Technology Avenue, Laishan District, Yantai 264003, Shandong Province, China. zhg10087@163.com
Key Words	Cartilage regeneration; Mesenchymal stem cells; Induced pluripotent stem cells; Tissue engineering; Three-dimensional bioprinting; Osteoarthritis; Gene editing
Core Tip	This review highlights the emerging role of stem cell-based strategies in articular cartilage regeneration. By integrating the biological potential of mesenchymal stem cells and induced pluripotent stem cells with engineering advances such as bioactive scaffolds, growth factor delivery, and three-dimensional bioprinting, these approaches aim to overcome the limitations of traditional therapies. We also discuss cutting-edge developments including gene editing and exosome-based therapeutics, offering new insights into personalized and durable cartilage repair solutions.
Citation	Cong B, Zhang FH, Zhang HG. Stem cell-based cartilage regeneration: Biological strategies, engineering innovations, and clinical translation. World J Stem Cells 2025; In press

Received	2025-04-17 03:26
Peer-Review Started	2025-04-17 03:26
To Make the First Decision
Return for Revision	2025-05-13 12:26
Revised	2025-05-27 11:30
Second Decision	2025-07-07 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-08 06:55
Articles in Press	2025-07-08 06:55
Publication Fee Transferred	2025-05-28 12:16
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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