Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	108535
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Interleukin-22 promotes cancer stemness and chemotherapy resistance in colorectal cancer via epidermal growth factor receptor/extracellular signal-regulated kinase pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Hong-Xun Ruan, Yan-Le Fang, Xiao-Ning Qin and Lin Lin
Funding Agency and Grant Number
Corresponding Author	Lin Lin, MD, The Third Department of General Surgery, The second Hospital of Hebei Medical University, No. 215 Heping West Road, Shijiazhuang 050004, Hebei Province, China. linlin779242000@163.com
Key Words	Interleukin-22; Colorectal cancer; Oxaliplatin; Epidermal growth factor receptor; Extracellular signal-regulated kinase
Core Tip	This study reveals that interleukin-22 (IL-22) enhances stem cell-like traits and promotes resistance to oxaliplatin in colorectal cancer (CRC) cells. Mechanistically, IL-22 activates the epidermal growth factor receptor (EGFR)/extracellular signal-regulated kinase signaling pathway. Inhibition of EGFR with osimertinib reverses IL-22-induced chemoresistance. These findings highlight IL-22 as a critical mediator of therapeutic resistance and a potential target for overcoming drug resistance in CRC treatment.
Citation	Ruan HX, Fang YL, Qin XN, Lin L. Interleukin-22 promotes cancer stemness and chemotherapy resistance in colorectal cancer via epidermal growth factor receptor/extracellular signal-regulated kinase pathway. World J Gastrointest Oncol 2025; In press

Received	2025-04-17 03:28
Peer-Review Started	2025-04-17 03:28
To Make the First Decision
Return for Revision	2025-05-13 12:01
Revised	2025-05-26 01:47
Second Decision	2025-07-11 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-11 09:36
Articles in Press	2025-07-11 09:36
Publication Fee Transferred	2025-05-28 09:06
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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