| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Nitidine chloride may mediate its antitumor effects by targeting kinesin family member 20A in colorectal cancer cells
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ke-Jun wu, Da-Tong Zeng, Rong-Quan He, Dong-Ming Li, Jin-Lian Yao, Li-Min Liu, Wei-Jian Huang, Di-Yuan Qin, Yu-Feng Li, Han He, Shi-De Li, Jia-Ying Wen, Li Meng, Jia-Rong Shi, Gang Chen and Hui Li |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Promoting Project of Basic Capacity for Young and Middle-aged University Teachers in Guangxi |
2025KY0164 |
| Youth Science Foundation of Guangxi Medical University |
GXMUYSF202423 |
| Guangxi Zhuang Autonomous Region Health Commission Scientific Research Project |
Z-A20220415 |
| Guangxi Zhuang Autonomous Region Health Commission Scientific Research Project |
Z20210442 |
|
| Corresponding Author |
Hui Li, MD, PhD, Department of Colorectal and Anal Surgery, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. lihui_gxmu@163.com |
| Key Words |
Nitidine chloride; Kinesin family member 20A; Colorectal cancer; Molecular docking; Single-cell sequencing; Clustered regularly interspaced short palindromic repeat screening |
| Core Tip |
In this study, we identified kinesin family member 20A (KIF20A) as a potential target for nitidine chloride (NC) in colorectal cancer (CRC) cells. Our multi-omics analysis revealed that KIF20A expression was elevated in CRC tissues, particularly in epithelial and proliferative regions, which correlated with clinical parameters. NC treatment significantly downregulated KIF20A in CRC cells, with molecular docking confirming direct binding, and knocking out KIF20A inhibited CRC cell growth. The pathway analysis suggests that NC suppresses CRC by disrupting mitosis, chromosome segregation, and microtubule dynamics by targeting KIF20A. |
| Citation |
Wu KJ, Zeng DT, He RQ, Li DM, Yao JL, Liu LM, Huang WJ, Qin DY, Li YF, He H, Li SD, Wen JY, Meng L, Shi JR, Chen G, Li H. Nitidine chloride may mediate its antitumor effects by targeting kinesin family member 20A in colorectal cancer cells. World J Clin Oncol 2025; In press |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
