Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	108880
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Correlation between inflammatory markers and disease severity in ulcerative colitis
Manuscript Source	Unsolicited Manuscript
All Author List	Jie Fu and Yue-Yu Zhang
Funding Agency and Grant Number	Funding Agency Grant Number 2019 TCM Evidence-based Practice Capacity Building Project of the State Administration of Traditional Chinese Medicine No. 2019XZZX-ZJ006 2020 “Special Project on Traditional Chinese Medicine Ancient Books and Characteristic Technology Inheritance” No. 295
Corresponding Author	Jie Fu, MD, College of Traditional Chinese Medicine, Hubei University of Chinese Medicine, No. 188 Tanhualin, Wuhan 430065, Hubei Province, China. fujie266@126.com
Key Words	Ulcerative colitis; Disease severity; Inflammatory markers; Predictive value; Interleukin-6; Tumor necrosis factor-alpha; C-reactive protein
Core Tip	The study evaluated whether interleukin-6, tumor necrosis factor-α, and C-reactive protein levels correlate with the severity of ulcerative colitis (UC). Analyses confirm strong positive relationships, supporting their utility as noninvasive biomarkers for UC progression. Of note, the interleukin-6 + tumor necrosis factor-α + C-reactive protein combination outperformed single-marker testing in identifying severe UC cases.
Citation	Fu J, Zhang YY. Correlation between inflammatory markers and disease severity in ulcerative colitis. World J Gastrointest Surg 2025; In press

Received	2025-07-11 09:37
Peer-Review Started	2025-07-11 09:37
To Make the First Decision
Return for Revision	2025-08-01 08:46
Revised	2025-08-18 13:27
Second Decision	2025-10-21 03:07
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-21 07:42
Articles in Press	2025-10-21 07:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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