Publication Name	World Journal of Clinical Oncology
Manuscript ID	108937
Country	Chile

Category	Oncology
Manuscript Type	Minireviews
Article Title	Sidedness matters: Colon cancer outcomes in low-resource settings
Manuscript Source	Invited Manuscript
All Author List	Jaime González-Montero, Guillermo Valenzuela, Carlos I Rojas and Mauricio Burotto
Funding Agency and Grant Number
Corresponding Author	Jaime González-Montero, Assistant Professor, MD, PhD, Department of Oncology, Bradford Hill Clinical Research Center, Palestina 343, Fifth Floor, Recoleta, Santiago 8420383, Chile. jagonzalez@ug.uchile.cl
Key Words	Colon cancer; Sidedness; Tailored therapy; Mismatch repair; Consensus molecular subtypes
Core Tip	Colon tumor sidedness is a practical compass for determining treatment. This review synthesizes epidemiologic, molecular, and clinical differences between right-sided colon cancer (RCC) and left-sided colon cancer (LCC). Older patients with RCC more frequently exhibit microsatellite instability-high status/deficient mismatch repair (MMR), Kirsten rat sarcoma viral oncogene homolog/v-raf murine sarcoma viral oncogene homolog B1 mutations, poorer prognosis in metastatic disease, and limited benefit from anti-epidermal growth factor receptor (EGFR). LCC is more often RAS/v-raf murine sarcoma viral oncogene homolog B1 wild-type and EGFR-responsive. We propose a low-resource plan: Prioritize MMR immunohistochemistry; consider immunotherapy for deficient MMR/microsatellite instability-high; use 5-fluorouracil + leucovorin + oxaliplatin + irinotecan ± anti-angiogenic agents for RCC and doublet ± anti-angiogenic therapy for LCC; restrict anti-EGFR to confirmed wild-type disease.
Citation	González-Montero J, Valenzuela G, Rojas CI, Burotto M. Sidedness matters: Colon cancer outcomes in low-resource settings. World J Clin Oncol 2025; In press

Received	2025-04-27 15:55
Peer-Review Started	2025-04-27 15:55
To Make the First Decision
Return for Revision	2025-05-17 07:38
Revised	2025-05-27 13:55
Second Decision	2025-09-08 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-08 10:46
Articles in Press	2025-09-08 10:46
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Edit the Manuscript by Language Editor
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ISSN	2218-4333 (online)
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