Publication Name	World Journal of Clinical Cases
Manuscript ID	108942
Country	China

Category	Oncology
Manuscript Type	Case Report
Article Title	Kirsten rat sarcoma G12C inhibitor treatment for a patient with relapsed metastatic lung adenocarcinoma: A case report
Manuscript Source	Invited Manuscript
All Author List	Lei Gan, Jiao-Feng Shen, Meng-Xian Yao, Zhi-Gang Chen and Zhi-Xiang Zhuang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Sciences Foundation of China 81803553
Corresponding Author	Lei Gan, PhD, Department of Oncology, The Second Affiliated Hospital of Soochow University, No. 1055 Sanxiang Road, Gusu District, Suzhou 215004, Jiangsu Province, China. ganlei19870810@163.com
Key Words	Non-small cell lung cancer; Kirsten rat sarcoma G12C; Targeted therapy; Gene mutation; Case report
Core Tip	Non-small cell lung cancer represents 85% of all pulmonary malignancies globally. Kirsten rat sarcoma viral oncogene homolog (KRAS) is among the most common mutations observed in malignant tumors, with roughly 13% of pulmonary adenocarcinomas carrying the KRAS at glycine 12 to cysteine (G12C) mutation. In this case, the initial therapeutic strategies for KRAS G12C-mutant lung adenocarcinomas were similar to those for driver mutation-negative non-small cell lung cancer. Following relapse, with KRAS G12C inhibitor administration, the patient’s post-relapse progression-free survival reached 17 months. Subsequently, the patient’s disease progressed, necessitating renewed treatment with radiotherapy, chemotherapy, and targeted therapy.
Citation	Gan L, Shen JF, Yao MX, Chen ZG, Zhuang ZX. Kirsten rat sarcoma G12C inhibitor treatment for a patient with relapsed metastatic lung adenocarcinoma: A case report. World J Clin Cases 2025; In press

Received	2025-05-07 02:44
Peer-Review Started	2025-05-07 02:44
To Make the First Decision
Return for Revision	2025-05-17 07:57
Revised	2025-05-31 13:34
Second Decision	2025-09-08 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-08 09:09
Articles in Press	2025-09-08 09:09
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Edit the Manuscript by Language Editor
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ISSN	2307-8960 (online)
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