Publication Name	World Journal of Clinical Oncology
Manuscript ID	108954
Country	China

Category	Oncology
Manuscript Type	Minireviews
Article Title	Neuro-tumor interactions: Multi-dimensional mechanisms of neurotransmitter regulation in tumor immune evasion and metabolic reprogramming
Manuscript Source	Invited Manuscript
All Author List	Ze-Kai Li, Jia-Lin Liao, Min-Rui Luo, Shu-Jie Fang, Wei-Zhen Huang and Dong-Yan Zhang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82272719 Natural Science Foundation of Guangdong Province No. 2023A1515012724 and No. 2024A1515013249 Science and Technology Projects in Guangzhou No. 2024A04J5205
Corresponding Author	Dong-Yan Zhang, Research Fellow, Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, No. 1838 North Guangzhou Avenue, Guangzhou 510515, Guangdong Province, China. 15013091401@163.com
Key Words	Tumor microenvironment; Neurotransmitter signaling; Metabolic reprogramming; Immune evasion; Immunotherapy
Core Tip	This article presents a novel perspective on the role of neural signaling in orchestrating tumor progression through the neuro-metabolic-immune axis within the tumor microenvironment. It illustrates that neurotransmitters can directly regulate immune evasion while also mediating metabolic reprogramming, thereby indirectly facilitating immunosuppression. This integrative framework unveils a dynamic bidirectional network wherein neural signals coordinate both metabolic and immune adaptations, offering new therapeutic targets aimed at disrupting this axis to enhance conventional cancer treatments.
Citation	Li ZK, Liao JL, Luo MR, Fang SJ, Huang WZ, Zhang DY. Neuro-tumor interactions: Multi-dimensional mechanisms of neurotransmitter regulation in tumor immune evasion and metabolic reprogramming. World J Clin Oncol 2025; In press

Received	2025-04-27 16:22
Peer-Review Started	2025-04-27 16:22
To Make the First Decision
Return for Revision	2025-05-22 11:13
Revised	2025-06-02 05:48
Second Decision	2025-09-15 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-17 10:07
Articles in Press	2025-09-17 10:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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