Publication Name	World Journal of Hepatology
Manuscript ID	109051
Country	China

Category	Oncology
Manuscript Type	Minireviews
Article Title	PANoptosis in hepatocellular carcinoma: Underlying mechanisms
Manuscript Source	Invited Manuscript
All Author List	Meng-Jia Li, Chen-Lin Wen, Hai-Tao Cheng, Hao-Nan Lyu and Yang-Yang Han
Funding Agency and Grant Number	Funding Agency Grant Number Xinjiang Key Laboratory of Molecular Biology for Endemic Diseases No. XJDFB2024G02 National Natural Science Foundation of China No. 82260493
Corresponding Author	Yang-Yang Han, Associate Professor, PhD, Department of Biology, School of Basic Medical Sciences, Xinjiang Medical University, No. 567 Shangde North Road, Urumqi 830017, Xinjiang Uygur Autonomous Region, China. yyhan@xjmu.edu.cn
Key Words	PANoptosis; Hepatocellular carcinoma; Programmed cell death; Mechanisms; Treatment strategies
Core Tip	This article interprets the specific mechanisms of PANoptosis in hepatocellular carcinoma (HCC) and explores potential therapeutic strategies, highlighting the promise of targeting PANoptosis for HCC treatment. While modulating PANoptosis in liver cancer cells can influence tumor progression, excessive activation of PANoptosis may trigger an inflammatory storm. We summarize current research on the mechanisms and therapies related to PANoptosis in HCC, aiming to provide possible treatment strategies for the disease.
Citation	Li MJ, Wen CL, Cheng HT, Lyu HN, Han YY. PANoptosis in hepatocellular carcinoma: Underlying mechanisms. World J Hepatol 2025; In press

Received	2025-04-29 05:55
Peer-Review Started	2025-05-07 09:18
To Make the First Decision
Return for Revision	2025-05-22 11:22
Revised	2025-06-05 09:20
Second Decision	2025-10-11 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-11 13:02
Articles in Press	2025-10-11 13:02
Publication Fee Transferred
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Typeset the Manuscript

ISSN	1948-5182 (online)
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