| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Observational Study |
| Article Title |
Poor sleep and hepatic steatosis contribute to poorer quality of life in people with human immunodeficiency virus
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Ana N Hyatt, Sai K Kuchana, Eduardo Vilar-Gomez, Richard K Sterling, Susanna Naggie, Sonya L Heath, Jennifer C Price, Laura A Wilson, Holly Crandall, Samer Gawrieh, Naga Chalasani, Rohit Loomba, Mark S Sulkowski, Archita P Desai and Jordan E Lake |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institutes of Health |
R01DK121378 |
| National Institutes of Health |
R01DK126042 |
| National Institutes of Health |
P30DK120515 |
|
| Corresponding Author |
Ana N Hyatt, MD, Department of Medicine, Division of Infectious Diseases, UTHealth Houston, 6431 Fannin Street, Houston, TX 77030, United States. ana.n.hyatt@uth.tmc.edu |
| Key Words |
Metabolic dysfunction-associated steatotic liver disease; Human immunodeficiency virus; Health-related quality of life; Sleep disorders; Liver fibrosis |
| Core Tip |
The prevalence and burden of poor sleep in people with human immunodeficiency virus and metabolic dysfunction-associated steatotic liver disease (MASLD) and its impact on health-related quality of life (HRQoL) are not well described. We studied these complex relationships in a cohort of 1005 virologically suppressed adult people with human immunodeficiency virus and MASLD, who underwent vibration-controlled transient elastography and self-reported questionnaires at eight United States centers. MASLD prevalence was high, 64% had poor sleep quality and HRQoL was low overall. There was no association between MASLD and sleep quality but poor sleep, MASLD and liver fibrosis were independently associated with poor HRQoL. |
| Citation |
Hyatt AN, Kuchana SK, Vilar-Gomez E, Sterling RK, Naggie S, Heath SL, Price JC, Wilson LA, Crandall H, Gawrieh S, Chalasani N, Loomba R, Sulkowski MS, Desai AP, Lake JE. Poor sleep and hepatic steatosis contribute to poorer quality of life in people with human immunodeficiency virus. World J Gastroenterol 2025; In press |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
