Publication Name	World Journal of Nephrology
Manuscript ID	109420
Country	Tunisia

Category	Urology & Nephrology
Manuscript Type	Case Report
Article Title	Renal involvement in Fabry disease from Tunisian families: Six case reports
Manuscript Source	Unsolicited Manuscript
All Author List	Syrine Tlili, Hiba Ghabi, Ikram Mami, Fethi Ben Hmida, Lamia Rais and Mohamed Karim Zouaghi
Funding Agency and Grant Number
Corresponding Author	Syrine Tlili, Associate Professor, Department of Nephrology, Dialysis and Transplantation, La Rabta Hospital, Street Jebberi, Tunis 1007, Tunisia. syrine.tlili@fmt.utm.tn
Key Words	Fabry disease; Chronic kidney disease; Genetic disorder; X-linked disorder; Case report
Core Tip	Fabry disease is a rare genetic disorder with variable clinical expression, often underdiagnosed in developing countries. Renal involvement, although frequent and prognostically significant, may be subtle or misattributed to more common nephropathies. This report of six related cases highlights the diagnostic challenges in recognizing Fabry nephropathy, particularly where access to genetic testing and renal biopsy is limited. Early identification through family screening and targeted evaluation is crucial to improve renal outcomes, especially in low-resource settings.
Citation	Tlili S, Ghabi H, Mami I, Ben Hmida F, Rais L, Zouaghi MK. Renal involvement in Fabry disease from Tunisian families: Six case reports. World J Nephrol 2026; In press

Received	2025-05-12 02:32
Peer-Review Started	2025-05-13 08:49
First Decision by Editorial Office Director	2025-06-07 02:19
Return for Revision	2025-06-07 02:19
Revised	2025-06-20 11:04
Publication Fee Transferred
Second Decision by Editor	2026-03-27 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-27 07:28
Articles in Press	2026-03-27 07:28
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	Fabry disease is a rare genetic disorder with variable clinical expression, often underdiagnosed in developing countries. Renal involvement, although frequent and prognostically significant, may be subtle or misattributed to more common nephropathies. This report of six related cases highlights the diagnostic challenges in recognizing Fabry nephropathy, particularly where access to genetic testing and renal biopsy is limited. Early identification through family screening and targeted evaluation is crucial to improve renal outcomes, especially in low-resource settings.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com