| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
N7-methylguanosine-related gene decapping scavenger enzymes as a novel biomarker regulating epithelial cell function in diabetic foot ulcers
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fu-Gang Xiao, Zhou Yang, Shi-Yan Yu, Qin Li, Peng-Cheng Huang, Guang-Bin Huang, Xiao-Gang Li, Jun-Lin Ran, Shun-Li Rui and Wu-Quan Deng |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82370903 |
| Noncommunicable Chronic Diseases-National Science and Technology Major Project |
2023ZD0509400 |
| Noncommunicable Chronic Diseases-National Science and Technology Major Project |
2023ZD0509402 |
| 2023 Key Disciplines on Public Health Construction of Chongqing, the Natural Science Foundation of Chongqing Municipal Science and Technology Bureau |
cstc2024ycjh-bgzxm0014 |
| Major Project of Science and Technology Research Program of Chongqing Education Commission of China |
KJZD-M202400102 |
|
| Corresponding Author |
Wu-Quan Deng, Chief Physician, PhD, Tenured Professor, Visiting Professor, Department of Endocrinology and Metabolism, Chongqing University Central Hospital, Chongqing Emergency Medical Centre, School of Medicine, Chongqing University, No. 1 Jiankang Road, Chongqing 400014, China. wuquandeng@cqu.edu.cn |
| Key Words |
Diabetic foot ulcer; N7-methylguanosine; Decapping scavenger enzyme; Biomarker; Normal human epidermal keratinocytes; Cell cycle |
| Core Tip |
This study identified decapping scavenger enzyme (DCPS) as a potential biomarker and therapeutic target for diabetic foot ulcers. It demonstrated that DCPS regulated m7G methylation, which affected cell cycle progression, proliferation, and migration of epithelial cells, which are crucial for wound healing. DCPS expression was significantly reduced in diabetic foot ulcer patients and diabetic mouse models, and its knockdown disrupted cell function, making it a promising target for improving healing in chronic nonhealing wounds. |
| Citation |
Xiao FG, Yang Z, Yu SY, Li Q, Huang PC, Huang GB, Li XG, Ran JL, Rui SL, Deng WQ. N7-methylguanosine-related gene decapping scavenger enzymes as a novel biomarker regulating epithelial cell function in diabetic foot ulcers. World J Diabetes 2025; In press |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
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|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
