Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	109481
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Myc-associated zinc finger protein drives colorectal cancer metastasis through activating ubiquitin like with ring finger protein one
Manuscript Source	Unsolicited Manuscript
All Author List	Hui-Qin Mao, Fang-Cao Yu, Dan-Qiong Hu and Li-Jing Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Hangzhou Medical and Health Science and Technology Plan B20210014
Corresponding Author	Hui-Qin Mao, Department of Ultrasonography, The Third People’s Hospital of Yuhang District, No. 8 Yangshanwan Road, Pingyao Town, Yuhang District, Hangzhou 311115, Zhejiang Province, China. 13968523585@163.com
Key Words	Colorectal cancer metastasis; Myc-associated zinc finger protein; Ubiquitin-like with PHD and RING finger domains 1; Esophageal cancer-related gene 4; DNA methylation
Core Tip	This study elucidated the oncogenic role of Myc-associated zinc finger protein (MAZ) in colorectal cancer (CRC), demonstrating its ability to promote cancer cell migration, invasion, and epithelial-mesenchymal transition by modulating the ubiquitin-like with PHD and RING finger domains 1-esophageal cancer-related gene 4 signaling pathway. MAZ was up-regulated in CRC cell species, and inhibition of its expression significantly inhibited cell invasion, invasion, epithelial-mesenchymal transition and tumor metastasis. Dual-luciferase reporter assay, chromatin immunoprecipitation quantitative polymerase chain reaction and methylation-specific polymerase chain reaction further validated the interaction of the MAZ-ubiquitin-like with PHD and RING finger domains 1-esophageal cancer-related gene 4 axis, providing convincing evidence for MAZ as a potential therapeutic target for CRC.
Citation	Mao HQ, Yu FC, Hu DQ, Zhang LJ. Myc-associated zinc finger protein drives colorectal cancer metastasis through activating ubiquitin like with ring finger protein one. World J Gastrointest Oncol 2025; In press

Received	2025-06-24 08:36
Peer-Review Started	2025-06-24 08:36
To Make the First Decision
Return for Revision	2025-07-15 06:30
Revised	2025-08-12 08:07
Second Decision	2025-10-20 02:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-20 07:39
Articles in Press	2025-10-20 07:39
Publication Fee Transferred	2025-08-20 08:44
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Typeset the Manuscript

ISSN	1948-5204 (online)
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