Publication Name	World Journal of Gastroenterology
Manuscript ID	109500
Country	China

Category	Oncology
Manuscript Type	Observational Study
Article Title	Serum exosomal hsa-let-7f-5p: A potential diagnostic biomarker for metastatic pancreatic cancer detection
Manuscript Source	Invited Manuscript
All Author List	Shuai Ren, Li-Na Song, Rui Zhao, Ying Tian and Zhong-Qiu Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82202135 National Natural Science Foundation of China 82371919 National Natural Science Foundation of China 82372017 National Natural Science Foundation of China 82171925 Jiangsu Provincial Key research and development program BE2023789 China Postdoctoral Science Foundation 2023M741808 Young Elite Scientists Sponsorship Program by China Association of Chinese Medicine 2024-QNRC2-B16 Young Elite Scientists Sponsorship Program by Jiangsu Association for Science and Technology JSTJ-2023-WJ027 Science and Technology Planning Project of Jiangsu Province BK20241994 Nanjing Postdoctoral Science Foundation, Natural Science Foundation of Nanjing University of Chinese Medicine XZR2023036 Foundation of Excellent Young Doctor of Jiangsu Province Hospital of Chinese Medicine 2023QB0112 Jiangsu Provincial Science and Technology Resources (Clinical Resources) Coordination Service Platform TC2023B003
Corresponding Author	Zhong-Qiu Wang, Chief Physician, Director, Head, Professor, Department of Radiology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, No. 155 Hanzhong Road, Nanjing 210029, Jiangsu Province, China. zhongqiuwang0815@163.com
Key Words	Serum exosomes; MicroRNA; Pancreatic cancer; Metastasis; Biomarker
Core Tip	Pancreatic cancer has a poor prognosis largely due to late-stage diagnosis and high metastatic potential. Exosomes, particularly exosome-derived microRNAs, have emerged as promising non-invasive biomarkers. This study identifies hsa-let-7f-5p as significantly upregulated in serum exosomes of metastatic pancreatic cancer patients. Validated through high-throughput sequencing and quantitative polymerase chain reaction, hsa-let-7f-5p shows potential for distinguishing metastatic from non-metastatic disease. Its target gene interactions further support its role in metastasis, offering new insights into pancreatic cancer progression and potential avenues for early detection and therapeutic intervention.
Citation	Ren S, Song LN, Zhao R, Tian Y, Wang ZQ. Serum exosomal hsa-let-7f-5p: A potential diagnostic biomarker for metastatic pancreatic cancer detection. World J Gastroenterol 2025; In press

Received	2025-05-14 03:11
Peer-Review Started	2025-05-14 03:11
To Make the First Decision
Return for Revision	2025-05-22 15:42
Revised	2025-06-05 02:43
Second Decision	2025-06-30 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-30 06:08
Articles in Press	2025-06-30 06:08
Publication Fee Transferred
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Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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