Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	109503
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Bidirectional regulation of the gut microbiome-immune axis in the immune microenvironment of colorectal cancer and targeted interventions
Manuscript Source	Unsolicited Manuscript
All Author List	Xin-Xin Liu, Bing Yang and Dong-Xin Tang
Funding Agency and Grant Number
Corresponding Author	Dong-Xin Tang, Chief Physician, MD, Professor, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guizhou University of Traditional Chinese Medicine, No. 4 Dongqing Road, Huaxi District, Guiyang 550025, Guizhou Province, China. tdx7712@163.com
Key Words	Microbiota-immune axis; Colorectal cancer; Immune microenvironment; Bidirectional regulation; Targeted intervention
Core Tip	This review explores the bidirectional regulation of the microbiota-immune axis in the immune microenvironment of colorectal cancer (CRC). It discusses how gut microbiota influences immune responses and how the immune system modulates microbiota composition. Highlighting the complexity of these interactions, the review addresses unanswered questions about microbiota heterogeneity and its impact on therapeutic outcomes. It also examines targeted interventions and their potential to improve CRC treatment, offering new insights into both the basic mechanisms and clinical applications for effective therapy.
Citation	Liu XX, Yang B, Tang DX. Bidirectional regulation of the gut microbiome-immune axis in the immune microenvironment of colorectal cancer and targeted interventions. World J Gastrointest Oncol 2025; In press

Received	2025-06-05 09:19
Peer-Review Started	2025-06-05 09:19
To Make the First Decision
Return for Revision	2025-07-08 06:38
Revised	2025-07-18 09:26
Second Decision	2025-09-16 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-16 07:31
Articles in Press	2025-09-16 07:31
Publication Fee Transferred	2025-07-22 09:11
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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